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Tabernanthalog

Pharmaceutical compound From Wikipedia, the free encyclopedia

Tabernanthalog
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Tabernanthalog (TBG, DLX-007)[1] is a novel water-soluble, non-toxic ibogalog or simplified analogue of the psychoactive drug tabernanthine first synthesized by David E. Olson at UC Davis.

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Tabernanthalog is a non-hallucinogenic serotonin 5-HT2A receptor agonist.[2] It is also a serotonin 5-HT2B receptor antagonist.[2] The drug is described as having high selectivity for the serotonin 5-HT2 receptors.[2] Other targets of the drug include monoamine oxidase A (MAO-A), the α2A-adrenergic receptor, the serotonin 5-HT1B and 5-HT2C receptors, and the serotonin transporter (SERT).[2]

In rodents, it was found to promote structural neural plasticity, reduce drug seeking behavior, and produce antidepressant like effects.[1][3][4][5] It has also been shown that it effectively reduces motivation for heroin and alcohol in rats. This indicates its efficacy in animals with a history of heroin and alcohol polydrug use.[5]

Due to the rapidly-induced and enduring neuroplasticity, tabernanthalog is a member of the class of compounds known as non-hallucinogenic psychoplastogens.[1] This compound, as well as related compounds, are licensed by Delix Therapeutics and are being developed as potential medicines for neuropsychiatric disorders.[6]

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