6-Br-APB

This article is about the dopamine D1 receptor agonist. For the amphetamine derivative, see 6-APB.

6-Br-APB is a synthetic compound that acts as a selective D₁ agonist,^[1] with the (R)-enantiomer being a potent full agonist, while the (S) enantiomer retains its D₁ selectivity but is a weak partial agonist.^[2] (R)-6-Br-APB and similar D₁-selective full agonists like SKF-81,297 and SKF-82,958 produce characteristic anorectic effects, stereotyped behaviour and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.^[3][4][5]

6-Br-APB

Identifiers
IUPAC name 3-allyl-6-bromo-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
CAS Number	135974-57-1 N
PubChem CID	11957483
ChemSpider	8627436 Y
ChEMBL	ChEMBL34095 Y
CompTox Dashboard (EPA)	DTXSID40474680
Chemical and physical data
Formula	C19H20BrNO2
Molar mass	374.278 g·mol−1
3D model (JSmol)	Interactive image
SMILES c3ccccc3C2CN(CC=C)CCc(c1Br)c2cc(O)c1O
InChI InChI=1S/C19H20BrNO2/c1-2-9-21-10-8-14-15(11-17(22)19(23)18(14)20)16(12-21)13-6-4-3-5-7-13/h2-7,11,16,22-23H,1,8-10,12H2/t16-/m1/s1 Y Key:KKZGFVAZUKHFAC-MRXNPFEDSA-N Y
NY (what is this?)  (verify)