SKF-82,958

SKF-82,958 is a synthetic compound of the benzazepine class that acts as a D₁/D₅ receptor full agonist.^[1][2] SKF-82,958 and similar D₁-like-selective full agonists like SKF-81,297 and 6-Br-APB produce characteristic anorectic effects, hyperactivity and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulants such as amphetamine.^{[3][4][5][6][7][8][9][10][11]} SKF-82,958 was also subsequently found to act as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen.^[12][13]

SKF-82,958

Identifiers
IUPAC name 3-allyl-6-chloro-1-phenyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol
CAS Number	80751-65-1
PubChem CID	1225
ChemSpider	1188
UNII	7W60FE897Q
ChEMBL	ChEMBL317741
CompTox Dashboard (EPA)	DTXSID70894837
Chemical and physical data
Formula	C19H20ClNO2
Molar mass	329.82 g·mol−1
3D model (JSmol)	Interactive image
SMILES C=CCN1CCC2=C(C(=C(C=C2C(C1)C3=CC=CC=C3)O)O)Cl