AAK1

Adaptor-associated protein kinase 1 also known as AP2-associated protein kinase 1 is an enzyme that in humans is encoded by the AAK1 gene^[5][6][7] and is involved in clathrin mediated endocytosis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.^[7]

AAK1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WSQ, 5L4Q
Identifiers
Aliases	AAK1, AP2 associated kinase 1
External IDs	OMIM: 616405; MGI: 1098687; HomoloGene: 128746; GeneCards: AAK1; OMA:AAK1 - orthologs
EC number	2.7.11.1
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 69,457,997 bp[1] End 69,674,349 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 D1|6 37.75 cM Start 86,849,517 bp[2] End 87,003,223 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus renal medulla pons superior vestibular nucleus ventral tegmental area cardia Brodmann area 23 pylorus inferior ganglion of vagus nerve parietal lobe Top expressed in vestibular membrane of cochlear duct substantia nigra Paneth cell transitional epithelium of urinary bladder ciliary body subiculum retinal pigment epithelium pontine nuclei dentate gyrus of hippocampal formation granule cell medial dorsal nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity AP-2 adaptor complex binding nucleotide binding protein kinase activity Notch binding kinase activity protein binding ATP binding protein serine/threonine kinase activity Cellular component membrane plasma membrane terminal bouton cell leading edge clathrin-coated pit extrinsic component of plasma membrane clathrin-coated vesicle cytoplasm cytosol nucleus Biological process endocytosis phosphorylation protein stabilization regulation of protein localization protein autophosphorylation positive regulation of Notch signaling pathway protein phosphorylation regulation of clathrin-dependent endocytosis membrane organization regulation of endocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 22848 269774 Ensembl ENSG00000115977 ENSMUSG00000057230 UniProt Q2M2I8 Q3UHJ0 RefSeq (mRNA) NM_014911 NM_001371575 NM_001371577 NM_001040106 NM_177762 RefSeq (protein) NP_055726 NP_001358504 NP_001358506 NP_001035195 NP_808430 NP_001365581 NP_001365583 NP_001365584 Location (UCSC) Chr 2: 69.46 – 69.67 Mb Chr 6: 86.85 – 87 Mb PubMed search [3] [4]
Wikidata
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Function

Adaptor-related protein complex 2 (AP-2 complexes) functions during receptor-mediated endocytosis to trigger clathrin assembly, interact with membrane-bound receptors, and recruit endocytic accessory factors. This gene encodes a member of the SNF1 subfamily of Ser/Thr protein kinases. The protein interacts with and phosphorylates a subunit of the AP-2 complex, which promotes binding of AP-2 to sorting signals found in membrane-bound receptors and subsequent receptor endocytosis. Its kinase activity is stimulated by clathrin.^[7]