AATK

Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene.^[5][6][7]

AATK
Identifiers
Aliases	AATK, AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP, apoptosis-associated tyrosine kinase, aatyk1, mKIAA0641, apoptosis associated tyrosine kinase
External IDs	OMIM: 605276; MGI: 1197518; HomoloGene: 74861; GeneCards: AATK; OMA:AATK - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.3 Start 81,110,487 bp[1] End 81,166,221 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 119,898,139 bp[2] End 119,937,993 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve C1 segment inferior ganglion of vagus nerve olfactory bulb trigeminal ganglion right hemisphere of cerebellum subthalamic nucleus right frontal lobe ventral tegmental area putamen Top expressed in perirhinal cortex entorhinal cortex primary visual cortex CA3 field superior frontal gyrus cerebellar cortex dentate gyrus of hippocampal formation granule cell central gray substance of midbrain superior colliculus nucleus of stria terminalis More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein serine/threonine kinase activity protein binding protein kinase activity kinase activity transferase activity ATP binding Cellular component membrane perinuclear region of cytoplasm cytoplasm integral component of membrane cellular component Biological process phosphorylation protein phosphorylation biological process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9625 11302 Ensembl ENSG00000181409 ENSMUSG00000025375 UniProt Q6ZMQ8 Q80YE4 RefSeq (mRNA) NM_001080395 NM_004920 NM_001198785 NM_001198787 NM_007377 NM_001377503 RefSeq (protein) NP_001073864 NP_004911 NP_001185714 NP_001185716 NP_031403 NP_001364432 NP_001389718 Location (UCSC) Chr 17: 81.11 – 81.17 Mb Chr 11: 119.9 – 119.94 Mb PubMed search [3] [4]
Wikidata
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Structure and expression

The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids.^[5][6]

Function

The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells.^[7][8] Its suppressive role on melanoma development has been reported recently.^[9]

AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter.^[10]