ABCA9

ATP-binding cassette sub-family A member 9 is a protein that in humans is encoded by the ABCA9 gene.^[5]

ABCA9
Identifiers
Aliases	ABCA9, EST640918, ATP binding cassette subfamily A member 9
External IDs	OMIM: 612507; MGI: 2386796; HomoloGene: 33332; GeneCards: ABCA9; OMA:ABCA9 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q24.2 Start 68,974,488 bp[1] End 69,060,949 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E1 Start 109,991,575 bp[2] End 110,059,022 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastric mucosa tibial nerve sural nerve left ovary myocardium of left ventricle subcutaneous adipose tissue right ovary cardiac muscle tissue of right atrium pericardium apex of heart Top expressed in sciatic nerve ciliary body vestibular sensory epithelium stroma of bone marrow otolith organ iris utricle dermis umbilical cord conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ATPase activity ATP binding ATPase-coupled transmembrane transporter activity lipid transporter activity Cellular component integral component of membrane membrane intracellular membrane-bounded organelle Biological process lipid transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10350 217262 Ensembl ENSG00000154258 ENSMUSG00000041797 UniProt Q8IUA7 Q8K449 RefSeq (mRNA) NM_080283 NM_172386 NM_147220 RefSeq (protein) NP_525022 NP_671753 Location (UCSC) Chr 17: 68.97 – 69.06 Mb Chr 11: 109.99 – 110.06 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two transmembrane domains and two nucleotide binding folds. ABC proteins transport various molecules across extra- and intracellular membranes. This gene is a member of the ABCA subfamily and is clustered with four other ABCA subfamily members on chromosome 17q24. Transcriptional expression of this gene is induced during monocyte differentiation into macrophages and is suppressed by cholesterol import.^[5]