ABCB9

ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene.^[5][6]

ABCB9
Identifiers
Aliases	ABCB9, EST122234, TAPL, ATP binding cassette subfamily B member 9
External IDs	OMIM: 605453; MGI: 1861729; HomoloGene: 10491; GeneCards: ABCB9; OMA:ABCB9 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q24.31 Start 122,920,951 bp[1] End 122,981,649 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 F Start 124,199,593 bp[2] End 124,233,861 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell superficial temporal artery dorsal motor nucleus of vagus nerve right frontal lobe male germ cell right hemisphere of cerebellum sperm oocyte prefrontal cortex ventral tegmental area Top expressed in choroid plexus of fourth ventricle perirhinal cortex superior frontal gyrus entorhinal cortex primary visual cortex cerebellar cortex olfactory tubercle primary motor cortex CA3 field Medulla Oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity protein homodimerization activity transmembrane transporter activity ABC-type oligopeptide transporter activity ATP binding ABC-type peptide transporter activity ATPase-coupled transmembrane transporter activity protein binding peptide transmembrane transporter activity Cellular component integral component of membrane early endosome membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum lysosome lysosomal membrane intracellular membrane-bounded organelle Biological process transmembrane transport peptide transport antigen processing and presentation of peptide antigen via MHC class I protein transport oligopeptide transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23457 56325 Ensembl ENSG00000150967 ENSMUSG00000029408 UniProt Q9NP78 Q9JJ59 RefSeq (mRNA) NM_001243013 NM_001243014 NM_019624 NM_019625 NM_203444 NM_203445 NM_019875 RefSeq (protein) NP_001229942 NP_001229943 NP_062570 NP_062571 NP_982269 NP_063928 Location (UCSC) Chr 12: 122.92 – 122.98 Mb Chr 5: 124.2 – 124.23 Mb PubMed search [3] [4]
Wikidata
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The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications.^[6]

See also

• ATP-binding cassette transporter