ABCC10

Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ABCC10 gene.^[5][6]

ABCC10
Identifiers
Aliases	ABCC10, EST182763, MRP7, SIMRP7, ATP binding cassette subfamily C member 10
External IDs	OMIM: 612509; MGI: 2386976; HomoloGene: 58616; GeneCards: ABCC10; OMA:ABCC10 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6p21.1 Start 43,427,366 bp[1] End 43,450,427 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 C Start 46,614,147 bp[2] End 46,639,278 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum granulocyte right ovary pituitary gland anterior pituitary right adrenal cortex apex of heart left ovary epithelium of nasopharynx right frontal lobe Top expressed in substantia nigra trigeminal ganglion yolk sac spermatocyte neural layer of retina right kidney duodenum proximal tubule ascending aorta secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ATPase-coupled transmembrane transporter activity Cellular component integral component of membrane lysosomal membrane plasma membrane membrane integral component of plasma membrane Biological process transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89845 224814 Ensembl ENSG00000124574 ENSMUSG00000032842 UniProt Q5T3U5 Q8R4P9 RefSeq (mRNA) NM_001198934 NM_033450 NM_001350518 NM_145140 NM_170680 NM_001347396 RefSeq (protein) NP_001185863 NP_258261 NP_001337447 NP_001334325 NP_660122 NP_733780 Location (UCSC) Chr 6: 43.43 – 43.45 Mb Chr 17: 46.61 – 46.64 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This ABC full-transporter is a member of the MRP subfamily which is involved in multi-drug resistance. Alternative splicing of this gene results in multiple transcript variants; however, not all variants have been fully described.^[6]

See also

• ATP-binding cassette transporter