ABCC3

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene.^[4][5][6]

ABCC3
Identifiers
Aliases	ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2, ATP binding cassette subfamily C member 3
External IDs	OMIM: 604323; MGI: 1923658; HomoloGene: 68364; GeneCards: ABCC3; OMA:ABCC3 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse)[1] Band 11|11 D Start 94,234,121 bp[1] End 94,283,823 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right adrenal gland left adrenal gland right lobe of liver body of pancreas gallbladder rectum duodenum body of stomach pylorus Top expressed in transitional epithelium of urinary bladder spermatid left lobe of liver Ileal epithelium gastric mucosa mucous cell of stomach spermatocyte epithelium of stomach stroma of bone marrow duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase-coupled transmembrane transporter activity nucleotide binding organic anion transmembrane transporter activity ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ABC-type bile acid transporter activity ABC-type xenobiotic transporter activity transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane basolateral plasma membrane integral component of plasma membrane vacuolar membrane Biological process transmembrane transport bile acid and bile salt transport xenobiotic transmembrane transport xenobiotic transport canalicular bile acid transport organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8714 76408 Ensembl n/a ENSMUSG00000020865 UniProt O15438 B2RX12 RefSeq (mRNA) NM_001144070 NM_003786 NM_020037 NM_020038 NM_029600 NM_001363187 NM_001363189 RefSeq (protein) NP_001137542 NP_003777 NP_083876 NP_001350116 NP_001350118 Location (UCSC) n/a Chr 11: 94.23 – 94.28 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.^[6]

ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The constitutive androstane receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated induction in response to oxidative stress.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

• ATP-binding cassette transporter