ABCC5

Multidrug resistance-associated protein 5 is a protein that in humans is encoded by the ABCC5 gene.^[5][6][7]

ABCC5
Identifiers
Aliases	ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11, ATP binding cassette subfamily C member 5
External IDs	OMIM: 605251; MGI: 1351644; HomoloGene: 21164; GeneCards: ABCC5; OMA:ABCC5 - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q27.1 Start 183,919,934 bp[1] End 184,017,939 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 A3|16 12.41 cM Start 20,150,053 bp[2] End 20,245,144 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum middle temporal gyrus gastrocnemius muscle retinal pigment epithelium tibialis anterior muscle apex of heart primary visual cortex muscle of thigh Brodmann area 23 right frontal lobe Top expressed in superior frontal gyrus yolk sac neural layer of retina granulocyte primary visual cortex dentate gyrus of hippocampal formation granule cell gastrula decidua muscle of thigh cerebellar cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding organic anion transmembrane transporter activity ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ATPase-coupled transmembrane transporter activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process hyaluronan biosynthetic process organic anion transport transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10057 27416 Ensembl ENSG00000114770 ENSMUSG00000022822 UniProt O15440 Q9R1X5 RefSeq (mRNA) NM_001023587 NM_005688 NM_001320032 NM_013790 NM_176839 RefSeq (protein) NP_001018881 NP_001306961 NP_005679 NP_038818 NP_789809 Location (UCSC) Chr 3: 183.92 – 184.02 Mb Chr 16: 20.15 – 20.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance.

This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides.

Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercaptopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients.

Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear.^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.^{[§ 1]}

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|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

• ATP-binding cassette transporter