ABHD3

Alpha/beta hydrolase domain containing 3 (ABHD3; alternative names: lung alpha/beta hydrolase 3,^[5] phospholipase ABHD3) is a single pass type II membrane member of the serine hydrolase family of enzymes.^[6] The expression of murine ABHD3 is highest in the brain, liver, and kidney. ABHD3 hydrolytic activity is highly specific for medium chain (e.g., dimyristoylphosphatidylcholine) and oxidatively truncated (e.g., azelaoyl PAF) phospholipids. ABHD3-deficient mice are viable, fertile, and possess dramatically elevated medium chain phospholipids in tissues and in blood. Conversely, ectopic expression of ABHD3 prevents the accumulation of oxidized phospholipids in cells.

ABHD3
Identifiers
Aliases	ABHD3, LABH3, abhydrolase domain containing 3, abhydrolase domain containing 3, phospholipase
External IDs	OMIM: 612197; MGI: 2147183; HomoloGene: 14055; GeneCards: ABHD3; OMA:ABHD3 - orthologs
Gene location (Human) Chr. Chromosome 18 (human)[1] Band 18q11.2 Start 21,650,901 bp[1] End 21,704,780 bp[1]
Gene location (Mouse) Chr. Chromosome 18 (mouse)[2] Band 18|18 A1 Start 10,642,092 bp[2] End 10,706,771 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of colon mucosa of sigmoid colon rectum mucosa of transverse colon ventricular zone monocyte secondary oocyte islet of Langerhans duodenum Top expressed in deep cerebellar nuclei dorsal tegmental nucleus lobe of cerebellum medial vestibular nucleus olfactory epithelium globus pallidus cerebellar vermis epithelium of small intestine inferior colliculi ventral tegmental area More reference expression data BioGPS n/a
Gene ontology Molecular function 1-acyl-2-lysophosphatidylserine acylhydrolase activity phosphatidylserine 1-acylhydrolase activity phospholipase A2 activity carboxylic ester hydrolase activity hydrolase activity phospholipase A1 activity lipase activity short-chain carboxylesterase activity acylglycerol lipase activity Cellular component integral component of membrane plasma membrane membrane cellular component Biological process phosphatidylcholine biosynthetic process phosphatidylcholine metabolic process lipid metabolism cellular lipid metabolic process medium-chain fatty acid biosynthetic process medium-chain fatty acid catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 171586 106861 Ensembl ENSG00000158201 ENSMUSG00000002475 UniProt Q8WU67 Q91ZH7 RefSeq (mRNA) NM_001308256 NM_001308257 NM_138340 NM_134130 RefSeq (protein) NP_001295185 NP_001295186 NP_612213 NP_598891 Location (UCSC) Chr 18: 21.65 – 21.7 Mb Chr 18: 10.64 – 10.71 Mb PubMed search [3] [4]
Wikidata
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