ABI gene family member 3

ABI gene family member 3 (ABI3) also known as new molecule including SH3 (Nesh) is a protein that in humans is encoded by the ABI3 gene.^[5][6][7]

ABI3
Identifiers
Aliases	ABI3, NESH, SSH3BP3, ABI family member 3
External IDs	OMIM: 606363; MGI: 1913860; HomoloGene: 9505; GeneCards: ABI3; OMA:ABI3 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.32 Start 49,210,411 bp[1] End 49,223,225 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 D Start 95,720,900 bp[2] End 95,733,302 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte spleen monocyte blood testicle appendix parotid gland apex of heart lymph node upper lobe of left lung Top expressed in thymus mesenteric lymph nodes interventricular septum granulocyte spleen tail of embryo blood gastrula right lung lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding identical protein binding SH3 domain binding Cellular component cytoplasm intracellular anatomical structure membrane lamellipodium Biological process peptidyl-tyrosine phosphorylation regulation of cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51225 66610 Ensembl ENSG00000108798 ENSMUSG00000018381 UniProt Q9P2A4 Q8BYZ1 RefSeq (mRNA) NM_001135186 NM_016428 NM_001163464 NM_025659 RefSeq (protein) NP_001128658 NP_057512 NP_001156936 NP_079935 Location (UCSC) Chr 17: 49.21 – 49.22 Mb Chr 11: 95.72 – 95.73 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of an adaptor protein family. Members of this family encode proteins containing a homeobox homology domain, proline rich region and Src-homology 3 (SH3) domain. The encoded protein inhibits ectopic metastasis of tumor cells as well as cell migration. This may be accomplished through interaction with p21-activated kinases.^[7]

See also

• ABI1
• ABI2
• ABI3BP