ABI1

Abl interactor 1 also known as Abelson interactor 1 (Abi-1) is a protein that in humans is encoded by the ABI1 gene.^[5][6]

ABI1
Identifiers
Aliases	ABI1, ABI-1, ABLBP4, E3B1, NAP1BP, SSH3BP, SSH3BP1, abl interactor 1
External IDs	OMIM: 603050; MGI: 104913; HomoloGene: 38053; GeneCards: ABI1; OMA:ABI1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10p12.1 Start 26,746,593 bp[1] End 26,861,087 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 A3|2 15.18 cM Start 22,830,085 bp[2] End 22,930,253 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of nasopharynx amniotic fluid palpebral conjunctiva cartilage tissue oral cavity bronchial epithelial cell skin of arm bone marrow thymus mucosa of paranasal sinus Top expressed in mesenteric lymph nodes subiculum granulocyte lateral septal nucleus left lung lobe parotid gland lobe of cerebellum skin of external ear anterior amygdaloid area ventral tegmental area More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein tyrosine kinase activator activity protein-containing complex binding cytoskeletal protein binding protein binding SH3 domain binding cadherin binding Cellular component cytoplasm cytosol postsynaptic membrane cell projection postsynaptic density SCAR complex membrane filopodium growth cone plasma membrane synapse intracellular anatomical structure cell junction cell leading edge endoplasmic reticulum neuron projection extracellular exosome cytoskeleton nucleus lamellipodium filopodium tip Biological process somitogenesis megakaryocyte development Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of protein tyrosine kinase activity vascular endothelial growth factor receptor signaling pathway peptidyl-tyrosine phosphorylation viral process lamellipodium morphogenesis negative regulation of cell population proliferation dendrite morphogenesis actin polymerization or depolymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10006 11308 Ensembl ENSG00000136754 ENSMUSG00000058835 UniProt Q8IZP0 Q8CBW3 RefSeq (mRNA) NM_001012750 NM_001012751 NM_001012752 NM_001178116 NM_001178119 NM_001178120 NM_001178121 NM_001178122 NM_001178123 NM_001178124 NM_001178125 NM_005470 NM_001348029 NM_001348030 NM_001348031 NM_001348032 NM_001348033 NM_001348034 NM_001077190 NM_001077192 NM_001077193 NM_007380 NM_145994 NM_001331043 NM_001331044 NM_001331045 NM_001377510 NM_001377511 NM_001377512 NM_001377513 RefSeq (protein) NP_001012768 NP_001012769 NP_001012770 NP_001171587 NP_001171590 NP_001171591 NP_001171592 NP_001171593 NP_001171594 NP_001171595 NP_001171596 NP_005461 NP_001334958 NP_001334959 NP_001334960 NP_001334961 NP_001334962 NP_001334963 NP_001070658 NP_001070660 NP_001070661 NP_001317972 NP_001317973 NP_001317974 NP_031406 NP_666106 NP_001364439 NP_001364440 NP_001364441 NP_001364442 Location (UCSC) Chr 10: 26.75 – 26.86 Mb Chr 2: 22.83 – 22.93 Mb PubMed search [3] [4]
Wikidata
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Function

Abl interactor 1 has been found to form a complex with EPS8 and SOS1, and is thought to be involved in the transduction of signals from Ras to Rac. In addition, the encoded protein may play a role in the regulation of EGF-induced Erk pathway activation as well as cytoskeletal reorganization and EGFR signaling. Several transcript variants encoding multiple isoforms have been found for this gene.^[7]

Abi1 is adaptor protein. It interacts with c-Abl and WAVE2 which is an actin polymerization regulator. It is known that Abi1 enhances the phosphorylation of WAVE2 by c-Abl. The phosphorylation of c-Abl promotes actin polymerization. Furthermore, Abi1 is a component of the WAVE complex. Some research has shown that knockdown of Abi1 by siRNA promoted degradation of WAVE complex proteins.^{[citation needed]}

Interactions

ABI1 has been shown to interact with

ENAH,^[8] NCKAP1,^[9] EPS8,^{[6][8][9][10][11]} and SOS1.^[12]