ABLIM1

Actin binding LIM protein 1, also known as ABLIM1, is a protein which in humans is encoded by the ABLIM1 gene.^[5][6]

ABLIM1
Identifiers
Aliases	ABLIM1, ABLIM, LIMAB1, LIMATIN, abLIM-1, actin binding LIM protein 1
External IDs	OMIM: 602330; MGI: 1194500; HomoloGene: 40994; GeneCards: ABLIM1; OMA:ABLIM1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.3 Start 114,431,112 bp[1] End 114,768,061 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19 D2|19 52.09 cM Start 57,021,165 bp[2] End 57,303,351 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in myocardium of left ventricle cerebellar vermis cardiac muscle tissue of right atrium right ventricle mucosa of pharynx cerebellar hemisphere parotid gland gums gingival epithelium oral cavity Top expressed in cardiac muscle tissue of left ventricle conjunctival fornix right ventricle thymus lobe of cerebellum cerebellar vermis esophagus epithelium of stomach mesenteric lymph nodes subcutaneous adipose tissue More reference expression data BioGPS More reference expression data
Gene ontology Molecular function actin binding protein binding metal ion binding actin filament binding Cellular component cytoplasm lamellipodium cytoskeleton stress fiber actin cytoskeleton Biological process animal organ morphogenesis cytoskeleton organization lamellipodium assembly visual perception cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3983 226251 Ensembl ENSG00000099204 ENSMUSG00000025085 UniProt O14639 Q8K4G5 RefSeq (mRNA) NM_001003407 NM_001003408 NM_002313 NM_006720 NM_001322882 NM_001322883 NM_001322884 NM_001322885 NM_001322886 NM_001322887 NM_001322888 NM_001322889 NM_001322890 NM_001322891 NM_001322892 NM_001322893 NM_001322894 NM_001322895 NM_001322896 NM_001322897 NM_001322898 NM_001322899 NM_001322900 NM_001352440 NM_001352441 NM_001352442 NM_001352443 NM_001103177 NM_001103178 NM_001290813 NM_001290815 NM_001290816 NM_178688 NM_001347459 NM_001362445 NM_001362446 RefSeq (protein) NP_001003407 NP_001309811 NP_001309812 NP_001309813 NP_001309814 NP_001309815 NP_001309816 NP_001309817 NP_001309818 NP_001309819 NP_001309820 NP_001309821 NP_001309822 NP_001309823 NP_001309824 NP_001309825 NP_001309826 NP_001309827 NP_001309828 NP_001309829 NP_002304 NP_006711 NP_001339369 NP_001339370 NP_001339371 NP_001339372 NP_001096647 NP_001096648 NP_001277742 NP_001277744 NP_001277745 NP_001334388 NP_848803 NP_001349374 NP_001349375 Location (UCSC) Chr 10: 114.43 – 114.77 Mb Chr 19: 57.02 – 57.3 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified.^[5]

Interactions

ABLIM1 has been shown to interact with LDOC1.^[7]