LDOC1

Protein LDOC1 is a protein that in humans is encoded by the LDOC1 gene.^[5][6][7][8]

LDOC1
Identifiers
Aliases	LDOC1, BCUR1, Mar7, Mart7, leucine zipper, down-regulated in cancer 1, regulator of NFKB signaling, SIRH7, RTL7, LDOC1 regulator of NFKB signaling
External IDs	OMIM: 300402; MGI: 2685212; HomoloGene: 32153; GeneCards: LDOC1; OMA:LDOC1 - orthologs
Gene location (Human) Chr. X chromosome (human)[1] Band Xq27.1 Start 141,111,605 bp[1] End 141,177,129 bp[1]
Gene location (Mouse) Chr. X chromosome (mouse)[2] Band X|X A6 Start 60,753,103 bp[2] End 60,754,561 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta ascending aorta right coronary artery popliteal artery tibial arteries anterior pituitary prefrontal cortex left coronary artery right frontal lobe dorsolateral prefrontal cortex Top expressed in lumbar subsegment of spinal cord facial motor nucleus embryo embryo blastocyst cerebellar cortex substantia nigra yolk sac anterior horn of spinal cord decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component nucleus nucleolus Biological process maternal placenta development maternal process involved in parturition regulation of growth hormone activity negative regulation of cell population proliferation cellular response to lipopolysaccharide cellular response to muramyl dipeptide Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23641 434784 Ensembl ENSG00000182195 ENSMUSG00000057615 UniProt O95751 Q7TPY9 RefSeq (mRNA) NM_012317 NM_001018087 RefSeq (protein) NP_036449 NP_001018097 Location (UCSC) Chr X: 141.11 – 141.18 Mb Chr X: 60.75 – 60.75 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.^[8]

Interactions

LDOC1 has been shown to interact with ABLIM1.^[9]