ACACA

Not to be confused with Acaçá.

Acetyl-CoA carboxylase 1 also known as ACC-alpha or ACCa is an enzyme that in humans is encoded by the ACACA gene.^[5][6]

ACACA
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YL2, 3COJ, 4ASI
Identifiers
Aliases	ACACA, ACAC, ACACAD, ACC, ACC1, ACCA, acetyl-CoA carboxylase alpha, ACACalpha, Acac1, hACC1, ACCalpha
External IDs	OMIM: 200350; MGI: 108451; HomoloGene: 31015; GeneCards: ACACA; OMA:ACACA - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q12 Start 37,084,992 bp[1] End 37,406,836 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 C Start 84,020,498 bp[2] End 84,292,477 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence corpus callosum ventricular zone superior frontal gyrus right adrenal cortex prefrontal cortex right frontal lobe prostate sural nerve dorsolateral prefrontal cortex Top expressed in brown adipose tissue mammary gland white adipose tissue subcutaneous adipose tissue mesenteric lymph nodes intercostal muscle aorta parotid gland otolith organ utricle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding metal ion binding biotin carboxylase activity ligase activity protein binding catalytic activity ATP binding identical protein binding acetyl-CoA carboxylase complex acetyl-CoA carboxylase activity Cellular component actin cytoskeleton fibrillar center cytoplasm cytosol Biological process carnitine shuttle malonyl-CoA biosynthetic process lipid metabolism fatty acid metabolic process cellular response to prostaglandin E stimulus fatty acid biosynthetic process tissue homeostasis acetyl-CoA metabolic process lipid homeostasis metabolism positive regulation of cellular metabolic process protein homotetramerization regulation of cholesterol biosynthetic process fatty-acyl-CoA biosynthetic process protein metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 31 107476 Ensembl ENSG00000278540 ENSG00000275176 ENSMUSG00000020532 UniProt Q13085 Q5SWU9 RefSeq (mRNA) NM_000664 NM_198834 NM_198835 NM_198836 NM_198837 NM_198838 NM_198839 NM_133360 RefSeq (protein) NP_942131 NP_942133 NP_942134 NP_942135 NP_942136 NP_579938 Location (UCSC) Chr 17: 37.08 – 37.41 Mb Chr 11: 84.02 – 84.29 Mb PubMed search [3] [4]
Wikidata
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Function

Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA.^[5]