ACBD3

Golgi resident protein GCP60 is a protein that in humans is encoded by the ACBD3 gene.^[5]

ACBD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2N72
Identifiers
Aliases	ACBD3, GCP60, GOCAP1, GOLPH1, PAP7, acyl-CoA binding domain containing 3
External IDs	OMIM: 606809; MGI: 2181074; HomoloGene: 11227; GeneCards: ACBD3; OMA:ACBD3 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.12 Start 226,144,679 bp[1] End 226,186,741 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H4|1 84.46 cM Start 180,553,608 bp[2] End 180,581,769 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibia buccal mucosa cell Epithelium of choroid plexus amniotic fluid gingival epithelium endothelial cell palpebral conjunctiva secondary oocyte cartilage tissue germinal epithelium Top expressed in secondary oocyte zygote primary oocyte medullary collecting duct aortic valve ascending aorta left colon urothelium umbilical cord parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein kinase A regulatory subunit binding protein binding fatty-acyl-CoA binding Cellular component integral component of membrane Golgi apparatus membrane mitochondrion Golgi membrane Biological process steroid biosynthetic process lipid metabolism transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64746 170760 Ensembl ENSG00000182827 ENSMUSG00000026499 UniProt Q9H3P7 Q8BMP6 RefSeq (mRNA) NM_022735 NM_133225 RefSeq (protein) NP_073572 NP_073572.2 NP_573488 Location (UCSC) Chr 1: 226.14 – 226.19 Mb Chr 1: 180.55 – 180.58 Mb PubMed search [3] [4]
Wikidata
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Function

The Golgi complex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. ACBD3 is involved in maintaining the Golgi structure by interacting with giantin, which affects the transport of protein.^[6] The protein encoded by this gene is involved in the maintenance of Golgi structure and function through its interaction with the integral membrane protein giantin. It may also be involved in the hormonal regulation of steroid formation.^[5]

Interactions

ACBD3 has been shown to interact with GOLGB1.^[7]