ACER1

Not to be confused with ACE1.

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the ACER1 gene.^[5]

ACER1
Identifiers
Aliases	ACER1, ALKCDase1, ASAH3, alkaline ceramidase 1
External IDs	OMIM: 613491; MGI: 2181962; HomoloGene: 15853; GeneCards: ACER1; OMA:ACER1 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 6,306,142 bp[1] End 6,333,612 bp[1]
Gene location (Mouse) Chr. Chromosome 17 (mouse)[2] Band 17|17 D Start 57,260,490 bp[2] End 57,289,126 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in skin of leg skin of abdomen skin of thigh vulva human penis nipple oral cavity vagina lymph node ectocervix Top expressed in skin of external ear lip condyle skin of back epithelium of stomach left colon epidermis skin of abdomen Paneth cell hair follicle More reference expression data BioGPS n/a
Gene ontology Molecular function dihydroceramidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity N-acylsphingosine amidohydrolase activity ceramidase activity metal ion binding Cellular component membrane integral component of membrane endoplasmic reticulum membrane endoplasmic reticulum Biological process cellular response to calcium ion regulation of lipid metabolic process cell differentiation sphingosine biosynthetic process sphingolipid biosynthetic process response to alkaline pH keratinocyte differentiation ceramide metabolic process epidermis development lipid metabolism ceramide catabolic process sphingolipid metabolic process regulation of water loss via skin sebaceous gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 125981 171168 Ensembl ENSG00000167769 ENSMUSG00000045019 UniProt Q8TDN7 Q8R4X1 RefSeq (mRNA) NM_133492 NM_175731 RefSeq (protein) NP_597999 NP_783858 Location (UCSC) Chr 19: 6.31 – 6.33 Mb Chr 17: 57.26 – 57.29 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).^[5]