ACER2

Alkaline ceramidase 2 also known as ACER2 is a ceramidase enzyme which in humans is encoded by the ACER2 gene.^[5]

ACER2
Identifiers
Aliases	ACER2, ALKCDase, ASAH3L, alkalina ceramidasa, ALKCDase2, alkaline ceramidase 2
External IDs	OMIM: 613492; MGI: 1920932; HomoloGene: 14986; GeneCards: ACER2; OMA:ACER2 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p22.1 Start 19,409,009 bp[1] End 19,452,505 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 C4 Start 86,792,633 bp[2] End 86,853,059 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in urinary bladder gonad placenta subcutaneous adipose tissue stomach testicle body of stomach duodenum body of pancreas islet of Langerhans Top expressed in transitional epithelium of urinary bladder right lung right lung lobe left lung embryo tail of embryo genital tubercle gastrula atrium left lung lobe More reference expression data BioGPS n/a
Gene ontology Molecular function dihydroceramidase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity N-acylsphingosine amidohydrolase activity ceramidase activity metal ion binding Cellular component integral component of membrane integral component of Golgi membrane Golgi apparatus membrane Golgi membrane Biological process positive regulation of cell death response to retinoic acid ceramide metabolic process lipid metabolism sphingosine biosynthetic process sphingolipid biosynthetic process negative regulation of cell-matrix adhesion positive regulation of cell population proliferation activation of cysteine-type endopeptidase activity involved in apoptotic process negative regulation of cell adhesion mediated by integrin cellular response to DNA damage stimulus regulation of autophagy DNA damage response, signal transduction by p53 class mediator regulation of apoptotic process ceramide catabolic process sphingolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 340485 230379 Ensembl ENSG00000177076 ENSMUSG00000038007 UniProt Q5QJU3 Q8VD53 RefSeq (mRNA) NM_001010887 NM_001290541 NM_001290543 NM_139306 NM_028605 RefSeq (protein) NP_001010887 NP_001277470 NP_001277472 NP_647467 Location (UCSC) Chr 9: 19.41 – 19.45 Mb Chr 4: 86.79 – 86.85 Mb PubMed search [3] [4]
Wikidata
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Function

The ACER2/sphingosine pathway plays an important role in regulating integrin β1 subunit (ITGB1) maturation and cell adhesion mediated by β1 integrins.^[6]