ACER3

Alkaline ceramidase 3 also known as ACER3 is a ceramidase enzyme which in humans is encoded by the ACER3 gene.^[5][6]

ACER3
Identifiers
Aliases	ACER3, APHC, PHCA, alkaline ceramidase 3, PLDECO
External IDs	OMIM: 617036; MGI: 1913440; HomoloGene: 5410; GeneCards: ACER3; OMA:ACER3 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.5 Start 76,860,859 bp[1] End 77,026,797 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E1 Start 98,206,389 bp[2] End 98,321,208 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell inferior ganglion of vagus nerve mucosa of ileum corpus callosum pancreatic epithelial cell pars reticulata pars compacta Brodmann area 46 subthalamic nucleus buccal mucosa cell Top expressed in conjunctival fornix cornea interventricular septum hair follicle skin of external ear sciatic nerve decidua skin of back lobe of prostate skin of abdomen More reference expression data BioGPS n/a
Gene ontology Molecular function hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity phytoceramidase activity N-acylsphingosine amidohydrolase activity dihydroceramidase activity ceramidase activity calcium ion binding zinc ion binding metal ion binding Cellular component integral component of membrane integral component of Golgi membrane integral component of endoplasmic reticulum membrane Golgi membrane Golgi apparatus endoplasmic reticulum membrane endoplasmic reticulum membrane Biological process sphingosine biosynthetic process sphingolipid biosynthetic process phytosphingosine biosynthetic process ceramide metabolic process positive regulation of cell population proliferation inflammatory response myelination regulation of programmed cell death ceramide catabolic process lipid metabolism sphingolipid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55331 66190 Ensembl ENSG00000078124 ENSMUSG00000030760 UniProt Q9NUN7 Q9D099 RefSeq (mRNA) NM_001300953 NM_001300954 NM_001300955 NM_018367 NM_025408 RefSeq (protein) NP_001287882 NP_001287883 NP_001287884 NP_060837 NP_079684 NP_001347544 NP_001347545 NP_001347546 Location (UCSC) Chr 11: 76.86 – 77.03 Mb Chr 7: 98.21 – 98.32 Mb PubMed search [3] [4]
Wikidata
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