ACOT7

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.^[5][6][7][8]

ACOT7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QQ2
Identifiers
Aliases	ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDs	OMIM: 602587; MGI: 1917275; HomoloGene: 15780; GeneCards: ACOT7; OMA:ACOT7 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.31 Start 6,264,269 bp[1] End 6,393,767 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 E2 Start 152,262,591 bp[2] End 152,356,312 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus prefrontal cortex right frontal lobe Brodmann area 9 pars compacta pons endothelial cell anterior cingulate cortex middle temporal gyrus spinal ganglia Top expressed in seminiferous tubule anterior horn of spinal cord medial dorsal nucleus facial motor nucleus dentate gyrus of hippocampal formation granule cell central gray substance of midbrain medulla oblongata nucleus of stria terminalis medial vestibular nucleus perirhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function palmitoyl-CoA hydrolase activity fatty-acyl-CoA binding protein homodimerization activity carboxylic ester hydrolase activity long-chain fatty acyl-CoA binding protein binding hydrolase activity acyl-CoA hydrolase activity myristoyl-CoA hydrolase activity thiolester hydrolase activity Cellular component cytosol nucleoplasm mitochondrion extracellular exosome cytoplasm Biological process medium-chain fatty acid biosynthetic process medium-chain fatty-acyl-CoA catabolic process long-chain fatty-acyl-CoA catabolic process coenzyme A biosynthetic process palmitic acid biosynthetic process acyl-CoA metabolic process lipid metabolism fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11332 70025 Ensembl ENSG00000097021 ENSMUSG00000028937 UniProt O00154 Q91V12 RefSeq (mRNA) NM_181866 NM_007274 NM_181862 NM_181863 NM_181864 NM_181865 NM_001146057 NM_001146058 NM_133348 NM_001369273 NM_001369274 NM_001369275 NM_001369276 RefSeq (protein) NP_009205 NP_863654 NP_863655 NP_863656 NP_001139529 NP_001139530 NP_579926 NP_001356202 NP_001356203 NP_001356204 NP_001356205 Location (UCSC) Chr 1: 6.26 – 6.39 Mb Chr 4: 152.26 – 152.36 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.^[8]