ACOT8

Acyl-coenzyme A thioesterase 8 is an enzyme that in humans is encoded by the ACOT8 gene.^{[5][6][7][8][9]}

ACOT8
Identifiers
Aliases	ACOT8, HNAACTE, PTE-1, PTE-2, PTE1, PTE2, hACTE-III, hTE, NAP1, acyl-CoA thioesterase 8
External IDs	OMIM: 608123; MGI: 2158201; HomoloGene: 3991; GeneCards: ACOT8; OMA:ACOT8 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q13.12 Start 45,841,721 bp[1] End 45,857,405 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2|2 H3 Start 164,634,685 bp[2] End 164,646,802 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon right adrenal gland right adrenal cortex prefrontal cortex left adrenal gland left adrenal cortex right frontal lobe cingulate gyrus anterior cingulate cortex apex of heart Top expressed in spermatid duodenum right kidney spermatocyte proximal tubule granulocyte jejunum colon left colon lip More reference expression data BioGPS More reference expression data
Gene ontology Molecular function palmitoyl-CoA hydrolase activity choloyl-CoA hydrolase activity long-chain acyl-CoA hydrolase activity carboxylic ester hydrolase activity medium-chain acyl-CoA hydrolase activity protein binding signaling receptor binding hydrolase activity CoA hydrolase activity acyl-CoA hydrolase activity acetyl-CoA hydrolase activity succinyl-CoA hydrolase activity acetoacetyl-CoA hydrolase activity hydroxymethylglutaryl-CoA hydrolase activity myristoyl-CoA hydrolase activity Cellular component cytoplasm peroxisome peroxisomal matrix cytosol Biological process peroxisome organization negative regulation of CD4 production alpha-linolenic acid metabolic process peroxisome fission dicarboxylic acid catabolic process fatty acid beta-oxidation using acyl-CoA oxidase viral process bile acid biosynthetic process fatty acid catabolic process acyl-CoA metabolic process protein targeting to peroxisome Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10005 170789 Ensembl ENSG00000101473 ENSMUSG00000017307 UniProt O14734 P58137 RefSeq (mRNA) NM_005469 NM_183385 NM_183386 NM_133240 NM_001362756 NM_001362757 RefSeq (protein) NP_005460 NP_573503 NP_001349685 NP_001349686 Location (UCSC) Chr 20: 45.84 – 45.86 Mb Chr 2: 164.63 – 164.65 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. Multiple transcript variants encoding several different isoforms have been found for this gene.^[9]