ACRV1

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene.^[5][6][7]

ACRV1
Identifiers
Aliases	ACRV1, D11S4365, SP-10, SPACA2, acrosomal vesicle protein 1
External IDs	OMIM: 102525; MGI: 104590; HomoloGene: 1219; GeneCards: ACRV1; OMA:ACRV1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q24.2 Start 125,671,522 bp[1] End 125,680,874 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 A4|9 20.67 cM Start 36,604,516 bp[2] End 36,610,139 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis sperm testicle gonad pancreatic ductal cell mucosa of ileum tibialis anterior muscle ventricular zone prefrontal cortex Top expressed in spermatid seminiferous tubule spermatocyte embryo seminal vesicula zygote secondary oocyte central gray substance of midbrain medial ganglionic eminence islet of Langerhans More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 56 11451 Ensembl ENSG00000134940 ENSMUSG00000032110 UniProt P26436 P50289 RefSeq (mRNA) NM_020115 NM_001612 NM_020069 NM_020107 NM_020108 NM_020109 NM_020110 NM_020111 NM_020112 NM_020113 NM_020114 NM_007391 RefSeq (protein) NP_001603 NP_064454 NP_064492 NP_064493 NP_031417 Location (UCSC) Chr 11: 125.67 – 125.68 Mb Chr 9: 36.6 – 36.61 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.^[7]