ACSL5

Long-chain-fatty-acid—CoA ligase 5 is an enzyme that in humans is encoded by the ACSL5 gene.^[5][6]

ACSL5
Identifiers
Aliases	ACSL5, ACS2, ACS5, FACL5, acyl-CoA synthetase long-chain family member 5, acyl-CoA synthetase long chain family member 5
External IDs	OMIM: 605677; MGI: 1919129; HomoloGene: 69208; GeneCards: ACSL5; OMA:ACSL5 - orthologs
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q25.2 Start 112,374,116 bp[1] End 112,428,379 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 D2 Start 55,240,370 bp[2] End 55,286,152 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of ileum corpus epididymis rectum mucosa of transverse colon mucosa of sigmoid colon duodenum right lobe of liver endometrium right uterine tube Top expressed in jejunum duodenum ileum skin of external ear migratory enteric neural crest cell transitional epithelium of urinary bladder epithelium of stomach left lobe of liver right lung right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ligase activity catalytic activity ATP binding long-chain fatty acid-CoA ligase activity decanoate-CoA ligase activity Cellular component integral component of membrane mitochondrial outer membrane nucleolus mitochondrial inner membrane nucleus membrane endoplasmic reticulum membrane endoplasmic reticulum mitochondrion Biological process regulation of extrinsic apoptotic signaling pathway lipid metabolism fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process metabolism long-chain fatty acid metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51703 433256 Ensembl ENSG00000197142 ENSMUSG00000024981 UniProt Q9ULC5 Q8JZR0 RefSeq (mRNA) NM_203380 NM_016234 NM_203379 NM_001387037 NM_027976 RefSeq (protein) NP_057318 NP_976313 NP_976314 NP_082252 Location (UCSC) Chr 10: 112.37 – 112.43 Mb Chr 19: 55.24 – 55.29 Mb PubMed search [3] [4]
Wikidata
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The protein encoded by this gene is an isozyme of the long-chain-fatty-acid-CoA ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in uterus and spleen, and in trace amounts in normal brain, but has markedly increased levels in malignant gliomas. This gene functions in mediating fatty acid-induced glioma cell growth. Three transcript variants encoding two different isoforms have been found for this gene.^[6]