ACSL6

Acyl-CoA synthetase long-chain family member 6 is an enzyme that in humans is encoded by the ACSL6 gene.^[5][6][7] Long-chain acyl-CoA synthetases such as ACSL6, catalyze the formation of acyl-CoA from fatty acids, ATP, and CoA.^[6]

ACSL6
Identifiers
Aliases	ACSL6, ACS2, FACL6, LACS 6, LACS2, LACS5, acyl-CoA synthetase long-chain family member 6, acyl-CoA synthetase long chain family member 6
External IDs	OMIM: 604443; MGI: 894291; HomoloGene: 100939; GeneCards: ACSL6; OMA:ACSL6 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 131,949,973 bp[1] End 132,012,243 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.3|11 32.13 cM Start 54,303,798 bp[2] End 54,364,756 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lateral nuclear group of thalamus Brodmann area 23 primary visual cortex right hemisphere of cerebellum pons seminal vesicula Brodmann area 9 endothelial cell right frontal lobe left testis Top expressed in olfactory epithelium retinal pigment epithelium deep cerebellar nuclei central gray substance of midbrain medial vestibular nucleus dorsal tegmental nucleus anterior horn of spinal cord inferior colliculi pontine nuclei neural layer of retina More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding protein homodimerization activity ligase activity catalytic activity enzyme binding ATP binding decanoate-CoA ligase activity long-chain fatty acid-CoA ligase activity Cellular component organelle membrane integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle plasma membrane peroxisomal membrane peroxisome mitochondrial outer membrane endoplasmic reticulum mitochondrion Biological process acyl-CoA metabolic process lipid metabolism fatty acid metabolic process long-chain fatty-acyl-CoA biosynthetic process metabolism long-chain fatty acid metabolic process neuroblast proliferation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23305 216739 Ensembl ENSG00000164398 ENSMUSG00000020333 UniProt Q9UKU0 Q91WC3 RefSeq (mRNA) NM_015256 NM_001009185 NM_001205247 NM_001205248 NM_001205250 NM_001205251 NM_001033597 NM_001033598 NM_001033599 NM_144823 RefSeq (protein) NP_001009185 NP_001192176 NP_001192177 NP_001192179 NP_001192180 NP_056071 NP_001028769 NP_001028770 NP_001028771 NP_659072 Location (UCSC) Chr 5: 131.95 – 132.01 Mb Chr 11: 54.3 – 54.36 Mb PubMed search [3] [4]
Wikidata
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Structure

The ACSL6 gene is located on the 5th chromosome, with its specific location being 5q31.1. The gene contains 23 exons.^[5] ACSL6 encodes a 77.7 kDa protein that is composed of 697 amino acids; 10 peptides have been observed through mass spectrometry data.^[8][9]