ACTR2

Actin-related protein 2 is a protein that in humans is encoded by the ACTR2 gene.^[5]

ACTR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI
Identifiers
Aliases	ACTR2, ARP2, ARP2 actin-related protein 2 homolog (yeast), ARP2 actin related protein 2 homolog, actin related protein 2
External IDs	OMIM: 604221; MGI: 1913963; HomoloGene: 4181; GeneCards: ACTR2; OMA:ACTR2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p14 Start 65,227,788 bp[1] End 65,271,253 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A3.1|11 12.88 cM Start 20,012,304 bp[2] End 20,062,913 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte trabecular bone epithelium of nasopharynx appendix palpebral conjunctiva lymph node mucosa of sigmoid colon bone marrow visceral pleura bone marrow cells Top expressed in stroma of bone marrow granulocyte tibiofemoral joint medial dorsal nucleus dorsal striatum trigeminal ganglion globus pallidus blood nucleus of stria terminalis Amygdala More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding actin filament binding structural constituent of cytoskeleton actin binding ATP binding cytoskeletal protein binding Cellular component cytoplasm cytosol cell projection membrane focal adhesion arp2/3 protein complex cell cortex actin cytoskeleton actin cap extracellular exosome cytoskeleton extracellular region postsynaptic density lamellipodium azurophil granule lumen ficolin-1-rich granule lumen podosome core Biological process cytosolic transport Fc-gamma receptor signaling pathway involved in phagocytosis actin filament organization ephrin receptor signaling pathway meiotic chromosome movement towards spindle pole meiotic cytokinesis establishment or maintenance of cell polarity meiosis asymmetric cell division Arp2/3 complex-mediated actin nucleation spindle localization actin cytoskeleton organization associative learning response to immobilization stress cellular response to trichostatin A neutrophil degranulation response to ethanol cilium assembly positive regulation of dendritic spine morphogenesis membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10097 66713 Ensembl ENSG00000138071 ENSMUSG00000020152 UniProt P61160 P61161 RefSeq (mRNA) NM_005722 NM_001005386 NM_146243 NM_001362899 RefSeq (protein) NP_001005386 NP_005713 NP_666355 NP_001349828 Location (UCSC) Chr 2: 65.23 – 65.27 Mb Chr 11: 20.01 – 20.06 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The specific function of ACTR2 has not yet been determined. However, it is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion. Two transcript variants encoding different isoforms have been found for this gene.^[6]