ACTR3

Actin-related protein 3 is a protein that in humans is encoded by the ACTR3 gene.^[5]

ACTR3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2P9N, 1TYQ, 1U2V, 4JD2, 3DXK, 3UKU, 3UKR, 2P9P, 2P9K, 2P9U, 3ULE, 3RSE, 2P9S, 2P9I, 4XF2, 2P9L, 1K8K, 3DXM, 4XEI
Identifiers
Aliases	ACTR3, ARP3, ARP3 actin-related protein 3 homolog (yeast), ARP3 actin related protein 3 homolog, actin related protein 3
External IDs	OMIM: 604222; MGI: 1921367; HomoloGene: 68483; GeneCards: ACTR3; OMA:ACTR3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q14.1 Start 113,890,063 bp[1] End 113,962,596 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 E2.3 Start 125,320,642 bp[2] End 125,363,464 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell sperm trabecular bone epithelium of nasopharynx gums gingival epithelium secondary oocyte oral cavity appendix amniotic fluid Top expressed in granulocyte thymus ileum spleen jejunum dentate gyrus of hippocampal formation granule cell placenta uterus colon tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function structural constituent of cytoskeleton nucleotide binding actin binding actin filament binding ATP binding protein binding Cellular component extracellular exosome brush border actin cytoskeleton cytoplasm cell projection cytosol lamellipodium cell-cell junction membrane focal adhesion cytoskeleton arp2/3 protein complex Biological process Fc-gamma receptor signaling pathway involved in phagocytosis ephrin receptor signaling pathway cilium assembly Arp2/3 complex-mediated actin nucleation meiosis spindle localization asymmetric cell division actin filament organization cell projection organization meiotic chromosome movement towards spindle pole establishment or maintenance of cell polarity meiotic cytokinesis membrane organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10096 74117 Ensembl ENSG00000115091 ENSMUSG00000026341 UniProt P61158 Q99JY9 RefSeq (mRNA) NM_001277140 NM_005721 NM_001205385 NM_001205386 NM_023735 RefSeq (protein) NP_001264069 NP_005712 NP_001192314 NP_001192315 NP_076224 Location (UCSC) Chr 2: 113.89 – 113.96 Mb Chr 1: 125.32 – 125.36 Mb PubMed search [3] [4]
Wikidata
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Function

The specific function of this gene has not yet been determined; however, the protein it encodes is known to be a major constituent of the ARP2/3 complex. This complex is located at the cell surface and is essential to cell shape and motility through lamellipodial actin assembly and protrusion.^[6]

Interactions

ACTR3 has been shown to interact with Cortactin.^[7][8]