ACVR2B

Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene.^[5][6][7] ACVR2B is an activin type 2 receptor.

ACVR2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2QLU, 4FAO, 2H62
Identifiers
Aliases	ACVR2B, ACTRIIB, ActR-IIB, HTX4, activin A receptor type 2B
External IDs	OMIM: 602730; MGI: 87912; HomoloGene: 863; GeneCards: ACVR2B; OMA:ACVR2B - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p22.2 Start 38,453,890 bp[1] End 38,493,142 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9|9 F3 Start 119,231,184 bp[2] End 119,264,061 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte ganglionic eminence endothelial cell parotid gland ventricular zone Skeletal muscle tissue of biceps brachii testicle retinal pigment epithelium lateral nuclear group of thalamus Skeletal muscle tissue of rectus abdominis Top expressed in Rostral migratory stream somite tail of embryo renal corpuscle epithelium of lens epiblast Ileal epithelium mandibular prominence embryo maxillary prominence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity growth factor binding activin binding metal ion binding kinase activity protein serine/threonine kinase activity transmembrane receptor protein serine/threonine kinase activity protein binding protein serine/threonine/tyrosine kinase activity activin receptor activity, type II ATP binding transforming growth factor beta-activated receptor activity transforming growth factor beta receptor activity, type II type I transforming growth factor beta receptor binding SMAD binding Cellular component cytoplasm integral component of membrane membrane receptor complex plasma membrane integral component of plasma membrane protein-containing complex activin receptor complex Biological process pattern specification process skeletal system development roof of mouth development regulation of transcription, DNA-templated organ growth embryonic foregut morphogenesis kidney development lymphangiogenesis lung development positive regulation of bone mineralization retina vasculature development in camera-type eye phosphorylation lymphatic endothelial cell differentiation skeletal system morphogenesis gastrulation with mouth forming second insulin secretion negative regulation of transcription by RNA polymerase II response to glucose post-embryonic development BMP signaling pathway venous blood vessel development odontogenesis of dentin-containing tooth protein phosphorylation heart development blood vessel remodeling determination of left/right symmetry positive regulation of osteoblast differentiation transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of activin receptor signaling pathway regulation of signal transduction artery development pancreas development mesoderm development activation of protein kinase activity signal transduction anterior/posterior pattern specification activin receptor signaling pathway transforming growth factor beta receptor signaling pathway negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 93 11481 Ensembl ENSG00000114739 ENSMUSG00000061393 UniProt Q13705 P27040 RefSeq (mRNA) NM_001106 NM_007397 NM_001313757 RefSeq (protein) NP_001097 NP_001300686 NP_031423 Location (UCSC) Chr 3: 38.45 – 38.49 Mb Chr 9: 119.23 – 119.26 Mb PubMed search [3] [4]
Wikidata
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Function

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.^[7]

Interactions

ACVR2B has been shown to interact with ACVR1B^[8][9] and SYNJ2BP.^[10]