ADAM11

Disintegrin and metalloproteinase domain-containing protein 11 is an enzyme that in humans is encoded by the ADAM11 gene.^[5][6]

ADAM11
Identifiers
Aliases	ADAM11, MDC, ADAM metallopeptidase domain 11
External IDs	OMIM: 155120; MGI: 1098667; HomoloGene: 7614; GeneCards: ADAM11; OMA:ADAM11 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q21.31 Start 44,758,988 bp[1] End 44,781,846 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 E1|11 66.48 cM Start 102,652,265 bp[2] End 102,671,088 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right hemisphere of cerebellum right frontal lobe prefrontal cortex cingulate gyrus anterior cingulate cortex Brodmann area 9 apex of heart superior frontal gyrus postcentral gyrus primary visual cortex Top expressed in cerebellar cortex primary visual cortex dentate gyrus of hippocampal formation granule cell superior frontal gyrus lobe of cerebellum liver parenchyma cerebellar vermis hippocampus proper habenula trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding metalloendopeptidase activity metallopeptidase activity Cellular component extracellular matrix integral component of membrane plasma membrane membrane collagen-containing extracellular matrix Biological process integrin-mediated signaling pathway proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4185 11488 Ensembl ENSG00000073670 ENSMUSG00000020926 UniProt O75078 Q9R1V4 RefSeq (mRNA) NM_002390 NM_001318933 NM_001110778 NM_009613 RefSeq (protein) NP_001305862 NP_002381 NP_001104248 NP_033743 Location (UCSC) Chr 17: 44.76 – 44.78 Mb Chr 11: 102.65 – 102.67 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor suppressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping.^[6]