ADAM19

ADAM19 (A Disintegrin And Metalloproteinase 19, MADDAM, meltrin beta), is a human gene.^[5]

ADAM19
Identifiers
Aliases	ADAM19, MADDAM, MLTNB, FKSG34, ADAM metallopeptidase domain 19
External IDs	OMIM: 603640; MGI: 105377; HomoloGene: 74925; GeneCards: ADAM19; OMA:ADAM19 - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q33.3 Start 157,395,534 bp[1] End 157,575,775 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B1.1|11 27.54 cM Start 45,946,819 bp[2] End 46,038,170 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte stromal cell of endometrium blood secondary oocyte sural nerve appendix saphenous vein lymph node granulocyte placenta Top expressed in gastrula decidua granulocyte atrium tail of embryo stroma of bone marrow facial motor nucleus endocardial cushion ascending aorta trigeminal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding peptidase activity metalloendopeptidase activity metallopeptidase activity hydrolase activity metal ion binding protein binding Cellular component integral component of membrane Golgi apparatus membrane plasma membrane nucleus collagen-containing extracellular matrix Biological process heart development membrane protein ectodomain proteolysis proteolysis extracellular matrix organization placenta development positive regulation of gene expression positive regulation of cell-cell adhesion mediated by cadherin Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8728 11492 Ensembl ENSG00000135074 ENSMUSG00000011256 UniProt Q9H013 O35674 RefSeq (mRNA) NM_023038 NM_033274 NM_001291890 NM_001291891 NM_009616 NM_001311209 RefSeq (protein) NP_150377 NP_001278819 NP_001278820 NP_001298138 NP_033746 Location (UCSC) Chr 5: 157.4 – 157.58 Mb Chr 11: 45.95 – 46.04 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has also been demonstrated to be an active metalloproteinase, which may be involved in normal physiological and pathological processes such as cells migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. Alternative splicing results in two transcript variants.^[5]

Interactions

ADAM19 has been shown to interact with ABI2.^[6]