ADAM2

Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin^[5] is an enzyme that in humans is encoded by the ADAM2 gene.^[6][7][8]

ADAM2
Identifiers
Aliases	ADAM2, CRYN1, CRYN2, CT15, FTNB, PH-30b, PH30, PH30-beta, ADAM metallopeptidase domain 2
External IDs	OMIM: 601533; MGI: 1340894; HomoloGene: 1127; GeneCards: ADAM2; OMA:ADAM2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p11.22 Start 39,743,735 bp[1] End 39,838,227 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 D1|14 34.36 cM Start 66,264,778 bp[2] End 66,315,182 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis testicle gonad placenta myeloid leukocyte monocyte prostate appendix Top expressed in spermatocyte spermatid seminiferous tubule morula blastocyst duodenum neural tube endocrine system islet of Langerhans digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding metalloendopeptidase activity metallopeptidase activity Cellular component integral component of membrane cell surface plasma membrane integral component of plasma membrane membrane protein-containing complex Biological process visual learning fusion of sperm to egg plasma membrane involved in single fertilization cell adhesion adult behavior proteolysis binding of sperm to zona pellucida single fertilization positive regulation of gene expression Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2515 11495 Ensembl ENSG00000104755 ENSG00000276286 ENSMUSG00000022039 UniProt Q99965 Q60718 RefSeq (mRNA) NM_001278113 NM_001278114 NM_001464 NM_009618 RefSeq (protein) NP_001265042 NP_001265043 NP_001455 NP_033748 Location (UCSC) Chr 8: 39.74 – 39.84 Mb Chr 14: 66.26 – 66.32 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.^[8] The other subunit is ADAM1 or alpha-fertilin.^[5]