ADAM23

Disintegrin and metalloproteinase domain-containing protein 23 is a non-catalytic protein that in humans is encoded by the ADAM23 gene.^[5][6] It is a member of the ADAM family of extracellular matrix metalloproteinases.

ADAM23
Identifiers
Aliases	ADAM23, MDC-3, MDC3, ADAM metallopeptidase domain 23
External IDs	OMIM: 603710; MGI: 1345162; HomoloGene: 2826; GeneCards: ADAM23; OMA:ADAM23 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.3 Start 206,443,532 bp[1] End 206,621,127 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C2|1 32.31 cM Start 63,485,050 bp[2] End 63,635,435 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 middle temporal gyrus Brodmann area 23 lateral nuclear group of thalamus primary visual cortex postcentral gyrus superior frontal gyrus Brodmann area 9 left ventricle nucleus accumbens Top expressed in facial motor nucleus superior frontal gyrus substantia nigra cerebellar cortex anterior horn of spinal cord pontine nuclei supraoptic nucleus primary visual cortex medial vestibular nucleus deep cerebellar nuclei More reference expression data BioGPS More reference expression data
Gene ontology Molecular function integrin binding metalloendopeptidase activity protein binding metallopeptidase activity Cellular component integral component of membrane extracellular region plasma membrane integral component of plasma membrane membrane glutamatergic synapse integral component of presynaptic membrane Biological process central nervous system development cell adhesion proteolysis cellular response to leukemia inhibitory factor Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8745 23792 Ensembl ENSG00000114948 ENSMUSG00000025964 UniProt O75077 Q9R1V7 RefSeq (mRNA) NM_003812 NM_001177600 NM_011780 RefSeq (protein) NP_003803 NP_035910 Location (UCSC) Chr 2: 206.44 – 206.62 Mb Chr 1: 63.49 – 63.64 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene is highly expressed in the brain and may function as an integrin ligand in the brain.^[6]