ADAM28

Disintegrin and metalloproteinase domain-containing protein 28 is an enzyme that in humans is encoded by the ADAM28 gene.^[5]

ADAM28
Identifiers
Aliases	ADAM28, ADAM 28, ADAM23, MDC-L, MDC-Lm, MDC-Ls, MDCL, eMDC II, eMDCII, ADAM metallopeptidase domain 28
External IDs	OMIM: 606188; MGI: 105988; HomoloGene: 40705; GeneCards: ADAM28; OMA:ADAM28 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8p21.2 Start 24,294,069 bp[1] End 24,359,014 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 D1 Start 68,843,476 bp[2] End 68,893,291 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in corpus epididymis nasal epithelium olfactory zone of nasal mucosa gallbladder pancreatic ductal cell right uterine tube epithelium of nasopharynx mucosa of paranasal sinus bronchial epithelial cell appendix Top expressed in superior surface of tongue gallbladder Ileal epithelium nasal epithelium olfactory epithelium transitional epithelium of urinary bladder corneal stroma plantaris muscle extensor digitorum longus muscle interventricular septum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity metal ion binding Cellular component integral component of membrane extracellular region membrane mitochondrion plasma membrane Biological process spermatogenesis proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10863 13522 Ensembl ENSG00000042980 ENSMUSG00000014725 UniProt Q9UKQ2 Q9JLN6 RefSeq (mRNA) NM_001304351 NM_014265 NM_021777 NM_001048175 NM_010082 NM_176991 NM_183366 RefSeq (protein) NP_001291280 NP_055080 NP_068547 NP_001041640 NP_034212 NP_899222 Location (UCSC) Chr 8: 24.29 – 24.36 Mb Chr 14: 68.84 – 68.89 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform.^[5]