ADAM33

Disintegrin and metalloproteinase domain-containing protein 33 is an enzyme that in humans is encoded by the ADAM33 gene.^[5][6]

ADAM33
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1R54, 1R55
Identifiers
Aliases	ADAM33, C20orf153, DJ964F7.1, ADAM metallopeptidase domain 33
External IDs	OMIM: 607114; MGI: 1341813; HomoloGene: 11881; GeneCards: ADAM33; OMA:ADAM33 - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20p13 Start 3,667,965 bp[1] End 3,682,246 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 F1|2 63.26 cM Start 130,892,511 bp[2] End 130,905,734 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in canal of the cervix body of uterus left uterine tube stromal cell of endometrium muscle layer of sigmoid colon ectocervix gastric mucosa Descending thoracic aorta ascending aorta myometrium Top expressed in ascending aorta aortic valve lip umbilical cord sciatic nerve dermis tunica media of zone of aorta muscle of thigh embryo superior frontal gyrus More reference expression data BioGPS n/a
Gene ontology Molecular function peptidase activity metalloendopeptidase activity protein binding hydrolase activity metallopeptidase activity metal ion binding zinc ion binding Cellular component integral component of membrane membrane Biological process proteolysis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80332 110751 Ensembl ENSG00000149451 ENSMUSG00000027318 UniProt Q9BZ11 Q08AM2 Q923W9 RefSeq (mRNA) NM_001282447 NM_025220 NM_153202 NM_001163529 NM_033615 RefSeq (protein) NP_001269376 NP_079496 NP_694882 NP_001157001 NP_291093 Location (UCSC) Chr 20: 3.67 – 3.68 Mb Chr 2: 130.89 – 130.91 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness.^[7] Alternative splicing of this gene results in two transcript variants encoding different isoforms.^[6]