ADAMTS1

A disintegrin and metalloproteinase with thrombospondin motifs 1 is an enzyme that in humans is encoded by the ADAMTS1 gene.^[5][6]

ADAMTS1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2JIH, 2V4B, 3Q2G, 3Q2H
Identifiers
Aliases	ADAMTS1, C3-C5, METH1, ADAM metallopeptidase with thrombospondin type 1 motif 1
External IDs	OMIM: 605174; MGI: 109249; HomoloGene: 21381; GeneCards: ADAMTS1; OMA:ADAMTS1 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 26,835,755 bp[1] End 26,845,409 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 48.2 cM Start 85,590,715 bp[2] End 85,600,001 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ovary left uterine tube vena cava left ovary pericardium gastric mucosa decidua tibial arteries mucosa of urinary bladder ascending aorta Top expressed in iris left lung lobe efferent ductule stroma of bone marrow ciliary body gastrula ascending aorta aortic valve vas deferens decidua More reference expression data BioGPS More reference expression data
Gene ontology Molecular function heparin binding zinc ion binding metal ion binding peptidase activity metalloendopeptidase activity hydrolase activity metallopeptidase activity Cellular component extracellular region basement membrane cytoplasmic vesicle extracellular matrix collagen-containing extracellular matrix Biological process ovulation from ovarian follicle heart trabecula formation kidney development proteolysis integrin-mediated signaling pathway negative regulation of cell population proliferation positive regulation of G1/S transition of mitotic cell cycle positive regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9510 11504 Ensembl ENSG00000154734 ENSMUSG00000022893 UniProt Q9UHI8 P97857 RefSeq (mRNA) NM_006988 NM_009621 RefSeq (protein) NP_008919 NP_033751 Location (UCSC) Chr 21: 26.84 – 26.85 Mb Chr 16: 85.59 – 85.6 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.^[6]

Interactions

ADAMTS1 has been shown to interact with Vascular endothelial growth factor A.^[7]