ADAMTS5

A disintegrin and metalloproteinase with thrombospondin motifs 5 also known as ADAMTS5 is an enzyme that in humans is encoded by the ADAMTS5 gene.^[5][6]

ADAMTS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RJQ, 3B8Z, 3HY7, 3HY9, 3HYG, 3LJT
Identifiers
Aliases	ADAMTS5, ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2, ADAM metallopeptidase with thrombospondin type 1 motif 5
External IDs	OMIM: 605007; MGI: 1346321; HomoloGene: 5109; GeneCards: ADAMTS5; OMA:ADAMTS5 - orthologs
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q21.3 Start 26,917,922 bp[1] End 26,967,088 bp[1]
Gene location (Mouse) Chr. Chromosome 16 (mouse)[2] Band 16 C3.3|16 48.34 cM Start 85,653,061 bp[2] End 85,698,716 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in lactiferous duct synovial joint stromal cell of endometrium skin of hip decidua synovial membrane Epithelium of choroid plexus endothelial cell buccal mucosa cell gastric mucosa Top expressed in decidua gastrula stroma of bone marrow white adipose tissue aortic valve ascending aorta sciatic nerve iris efferent ductule trigeminal ganglion More reference expression data BioGPS n/a
Gene ontology Molecular function heparin binding zinc ion binding extracellular matrix binding metal ion binding integrin binding peptidase activity protein binding hydrolase activity metallopeptidase activity metalloendopeptidase activity Cellular component endoplasmic reticulum lumen extracellular region extracellular space extracellular matrix collagen-containing extracellular matrix Biological process extracellular matrix disassembly proteolysis defense response to bacterium tooth eruption negative regulation of cold-induced thermogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11096 23794 Ensembl ENSG00000154736 ENSMUSG00000022894 UniProt Q9UNA0 Q9R001 RefSeq (mRNA) NM_007038 NM_011782 RefSeq (protein) NP_008969 NP_035912 Location (UCSC) Chr 21: 26.92 – 26.97 Mb Chr 16: 85.65 – 85.7 Mb PubMed search [3] [4]
Wikidata
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Function

ADAMTS5 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs and functions as aggrecanase to cleave aggrecan, a major proteoglycan of cartilage.^[7] ADAMTS5 may also have a role in the pathogenesis of human osteoarthritis.^[8]

Animal studies

Genetically modified mice in which the catalytic domain of ADAMTS5 was deleted are resistant to cartilage destruction in an experimental model of osteoarthritis.^[9] ADAMTS5 is the major aggrecanase in mouse cartilage in a mouse model of inflammatory arthritis.^[10]