ADAMTSL4

ADAMTS-like protein 4 is a protein that in humans is encoded by the ADAMTSL4 gene.^[5][6]

ADAMTSL4
Identifiers
Aliases	ADAMTSL4, ADAMTSL-4, ECTOL2, TSRC1, ADAMTS like 4
External IDs	OMIM: 610113; MGI: 2389008; HomoloGene: 23141; GeneCards: ADAMTSL4; OMA:ADAMTSL4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q21.2 Start 150,549,369 bp[1] End 150,560,937 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 F2.1 Start 95,583,511 bp[2] End 95,595,228 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua gastric mucosa tibial nerve left uterine tube muscle of thigh apex of heart upper lobe of left lung canal of the cervix Descending thoracic aorta body of uterus Top expressed in interventricular septum extraocular muscle muscle of thigh lip myocardium of ventricle ankle sciatic nerve right ventricle temporal muscle cardiac muscles More reference expression data BioGPS n/a
Gene ontology Molecular function protease binding peptidase activity protein binding Cellular component extracellular region interstitial matrix endoplasmic reticulum lumen cellular component extracellular matrix collagen-containing extracellular matrix Biological process positive regulation of apoptotic process extracellular matrix organization proteolysis apoptotic process epithelial cell development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54507 229595 Ensembl ENSG00000143382 ENSMUSG00000015850 UniProt Q6UY14 Q80T21 RefSeq (mRNA) NM_001288607 NM_001288608 NM_019032 NM_025008 NM_001378596 NM_001301705 NM_144899 RefSeq (protein) NP_001275536 NP_001275537 NP_061905 NP_079284 NP_001365525 NP_001288634 NP_659148 Location (UCSC) Chr 1: 150.55 – 150.56 Mb Chr 3: 95.58 – 95.6 Mb PubMed search [3] [4]
Wikidata
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Function

This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[6]