ADARB1

Double-stranded RNA-specific editase 1 is an enzyme that in humans is encoded by the ADARB1 gene.^[5][6][7] The enzyme is a member of ADAR family.

ADARB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1ZY7, 5ED1, 5ED2, 5HP3, 5HP2
Identifiers
Aliases	ADARB1, ADAR2, DRABA2, DRADA2, RED1, adenosine deaminase, RNA specific B1, adenosine deaminase RNA specific B1, NEDHYMS
External IDs	OMIM: 601218; MGI: 891999; HomoloGene: 8280; GeneCards: ADARB1; OMA:ADARB1 - orthologs
EC number	3.5.4.37
Gene location (Human) Chr. Chromosome 21 (human)[1] Band 21q22.3 Start 45,073,853 bp[1] End 45,226,560 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10 C1|10 39.72 cM Start 77,126,560 bp[2] End 77,254,104 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial arteries gastric mucosa right coronary artery cerebellar vermis saphenous vein lateral nuclear group of thalamus Descending thoracic aorta ascending aorta Achilles tendon left coronary artery Top expressed in medial dorsal nucleus medial geniculate nucleus lateral geniculate nucleus inferior colliculi cerebellar cortex Medulla Oblongata nucleus of stria terminalis dentate gyrus of hippocampal formation granule cell pontine nuclei visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding adenosine deaminase activity protein binding RNA binding double-stranded RNA binding mRNA binding hydrolase activity double-stranded RNA adenosine deaminase activity tRNA-specific adenosine deaminase activity Cellular component nucleoplasm nucleolus nucleus cytosol cytoplasm Biological process RNA processing immune system process mRNA processing base conversion or substitution editing regulation of cell cycle negative regulation of cell migration defense response to virus negative regulation of protein kinase activity by regulation of protein phosphorylation positive regulation of viral genome replication innate immune response adenosine to inosine editing negative regulation of cell population proliferation neuromuscular synaptic transmission facial nerve morphogenesis hypoglossal nerve morphogenesis spinal cord ventral commissure morphogenesis multicellular organism growth neuromuscular process controlling posture innervation muscle tissue morphogenesis motor behavior motor neuron apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 104 110532 Ensembl ENSG00000197381 ENSMUSG00000020262 UniProt P78563 Q91ZS8 RefSeq (mRNA) NM_001033049 NM_001112 NM_001160230 NM_015833 NM_015834 NM_001346687 NM_001346688 NM_001024837 NM_001024838 NM_001024839 NM_001024840 NM_130895 RefSeq (protein) NP_001103 NP_001153702 NP_001333616 NP_001333617 NP_056648 NP_056649 NP_001020008 NP_570965 NP_001020009 Location (UCSC) Chr 21: 45.07 – 45.23 Mb Chr 10: 77.13 – 77.25 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rats found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an Alu cassette insert and a short or long C-terminal region.^[7]

ADARB1 requires the small molecule inositol hexakisphosphate (IP₆) for proper function.^[8] ADARB1 is an A-to-I RNA-editing enzyme that mostly acts on protein-coding substrates.^[9]

See also

• Adenosine deaminase (ADA), an enzyme acting on isolated adenosine