ADCK2

ADCK2 (aarF domain containing kinase 2) is an enzyme that in humans is encoded by the ADCK2 gene. It is situated on chromosome 7 at the q34 location.

ADCK2
Identifiers
Aliases	ADCK2, AARF, aarF domain containing kinase 2
External IDs	MGI: 1889336; HomoloGene: 49103; GeneCards: ADCK2; OMA:ADCK2 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7q34 Start 140,672,945 bp[1] End 140,696,261 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6|6 B1 Start 39,550,807 bp[2] End 39,565,703 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell amniotic fluid prefrontal cortex mucosa of transverse colon testicle C1 segment skin of leg endothelial cell skin of abdomen nipple Top expressed in islet of Langerhans neural layer of retina hypothalamus spleen ovary granulocyte ganglionic eminence thymus renal cortex striatum of neuraxis More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity nucleotide binding protein serine/threonine kinase activity ATP binding kinase activity protein binding Cellular component integral component of membrane membrane Biological process protein phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 90956 57869 Ensembl ENSG00000133597 ENSMUSG00000046947 UniProt Q7Z695 Q6NSR3 RefSeq (mRNA) NM_052853 NM_178873 RefSeq (protein) NP_443085 NP_849204 Location (UCSC) Chr 7: 140.67 – 140.7 Mb Chr 6: 39.55 – 39.57 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

ADCK2 is predicted to possess ATP binding activity and protein serine/threonine kinase activity. The protein is predicted to be an integral part of the membrane.^[5]

Genomic context

The ADCK2 gene is located on chromosome 7q34. The genomic sequence spans 22,165 base pairs from 140,672,945 to 140,695,110 on the GRCh38.p14 primary assembly. It consists of 8 exons.^[5]

Expression

ADCK2 is ubiquitously expressed across various human tissues, with notable expression in skin and brain tissue, among others.^[5]

Clinical significance

Research indicates that ADCK2 may have therapeutic implications in diseases such as myopathy.^[6]