ADCK3

This article is about a protein and is not to be confused with ADCK.

aarF domain containing kinase 3 is a protein that in humans is encoded by the ADCK3 gene.^[5]

COQ8A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4PED
Identifiers
Aliases	COQ8A, ARCA2, CABC1, COQ10D4, COQ8, SCAR9, ADCK3, aarF domain containing kinase 3, coenzyme Q8A
External IDs	OMIM: 606980; MGI: 1914676; HomoloGene: 11345; GeneCards: COQ8A; OMA:COQ8A - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 226,940,286 bp[1] End 226,987,544 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H4 Start 179,992,803 bp[2] End 180,027,167 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle skeletal muscle tissue muscle of thigh apex of heart body of pancreas left ventricle right adrenal gland right adrenal cortex left adrenal gland left adrenal cortex Top expressed in extraocular muscle interventricular septum soleus muscle digastric muscle muscle of thigh sternocleidomastoid muscle tibialis anterior muscle temporal muscle masseter muscle myocardium of ventricle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding ADP binding protein binding ATP binding protein kinase activity kinase activity Cellular component integral component of membrane mitochondrion membrane extrinsic component of mitochondrial inner membrane Biological process ubiquinone biosynthetic process protein phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 56997 67426 Ensembl ENSG00000163050 ENSMUSG00000026489 UniProt Q8NI60 Q60936 RefSeq (mRNA) NM_020247 NM_001163290 NM_023341 NM_001359268 NM_001359269 RefSeq (protein) NP_064632 NP_001156762 NP_075830 NP_001346197 NP_001346198 Location (UCSC) Chr 1: 226.94 – 226.99 Mb Chr 1: 179.99 – 180.03 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined.^[5]