ADCK5

ADCK5 (aarF domain containing kinase 5) is an enzyme that in humans is encoded by the ADCK5 gene. It is situated on chromosome 8 at the q24.3 location.

ADCK5
Identifiers
Aliases	ADCK5, aarF domain containing kinase 5
External IDs	MGI: 2679274; HomoloGene: 34378; GeneCards: ADCK5; OMA:ADCK5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q24.3 Start 144,373,101 bp[1] End 144,393,242 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 D3 Start 76,460,558 bp[2] End 76,480,016 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon duodenum right hemisphere of cerebellum granulocyte right adrenal cortex left adrenal cortex gonad right lobe of liver spleen apex of heart Top expressed in adrenal gland jejunum duodenum left lobe of liver seminal vesicula blastocyst large intestine colon yolk sac lip More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity protein serine/threonine kinase activity protein binding kinase activity Cellular component integral component of membrane membrane Biological process protein phosphorylation phosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 203054 268822 Ensembl ENSG00000173137 ENSG00000285451 ENSMUSG00000022550 UniProt Q3MIX3 Q80V03 RefSeq (mRNA) NM_174922 NM_172960 RefSeq (protein) NP_777582 NP_766548 Location (UCSC) Chr 8: 144.37 – 144.39 Mb Chr 15: 76.46 – 76.48 Mb PubMed search [3] [4]
Wikidata
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Function

ADCK5 is predicted to possess protein serine/threonine kinase activity and to be an integral component of the membrane.^[5]

Genomic context

The ADCK5 gene is located on chromosome 8q24.3. The genomic sequence spans 20,154 base pairs from 144,373,088 to 144,393,242 on the GRCh38.p14 primary assembly. It consists of 19 exons.^[5]

Expression

ADCK5 is ubiquitously expressed across various human tissues, with notable expression in the duodenum and small intestine, among others.^[5]

Clinical significance

Research indicates that ADCK5 may have therapeutic implications in lung cancer.^[6]