ADCY1

Adenylyl cyclase type 1 is an enzyme that in humans is encoded by the ADCY1 gene.^[5][6]

ADCY1
Identifiers
Aliases	ADCY1, AC1, DFNB44, adenylate cyclase 1 (brain), adenylate cyclase 1
External IDs	OMIM: 103072; MGI: 99677; HomoloGene: 41419; GeneCards: ADCY1; OMA:ADCY1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p12.3 Start 45,574,140 bp[1] End 45,723,116 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 A1|11 4.72 cM Start 7,013,489 bp[2] End 7,128,506 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus Brodmann area 23 orbitofrontal cortex postcentral gyrus superior frontal gyrus Brodmann area 46 entorhinal cortex occipital lobe primary visual cortex cerebellar vermis Top expressed in lobe of cerebellum cerebellar vermis prefrontal cortex primary motor cortex hippocampus proper lateral geniculate nucleus dentate gyrus medial dorsal nucleus medial geniculate nucleus dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding calmodulin binding lyase activity phosphorus-oxygen lyase activity ATP binding adenylate cyclase activity guanylate cyclase activity calcium- and calmodulin-responsive adenylate cyclase activity Cellular component cytoplasm integral component of membrane membrane plasma membrane integral component of plasma membrane membrane raft extracellular exosome nucleus guanylate cyclase complex, soluble postsynaptic density Schaffer collateral - CA1 synapse hippocampal mossy fiber to CA3 synapse glutamatergic synapse integral component of postsynaptic density membrane Biological process cellular response to calcium ion activation of protein kinase A activity intracellular signal transduction cellular response to forskolin axonogenesis rhythmic process cellular response to glucagon stimulus cyclic nucleotide biosynthetic process response to lithium ion long-term memory regulation of circadian rhythm circadian rhythm renal water homeostasis activation of adenylate cyclase activity cAMP biosynthetic process cGMP biosynthetic process signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway cAMP-mediated signaling G protein-coupled receptor signaling pathway brain development positive regulation of CREB transcription factor activity modulation of chemical synaptic transmission neuroinflammatory response positive regulation of long-term synaptic potentiation regulation of synaptic vesicle exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 107 432530 Ensembl ENSG00000164742 ENSMUSG00000020431 UniProt Q08828 O88444 RefSeq (mRNA) NM_001281768 NM_021116 NM_009622 RefSeq (protein) NP_001268697 NP_066939 NP_033752 Location (UCSC) Chr 7: 45.57 – 45.72 Mb Chr 11: 7.01 – 7.13 Mb PubMed search [3] [4]
Wikidata
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This gene encodes a form of adenylyl cyclase expressed in the brain. A similar protein in mice is involved in pattern formation of the brain.^[6]

Function

ADCY1 is a calmodulin-sensitive adenylyl cyclase. In terms of function, It may be involved in regulatory processes in the central nervous system; specifically, it may play a role in memory acquisition and learning. It is inhibited by the G protein beta and gamma subunit complex.^[7]