ADCY10

See also: Soluble adenylyl cyclase

Adenylyl cyclase 10 also known as ADCY10 is an enzyme that, in humans, is encoded by the ADCY10 gene.^[5]

ADCY10
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4CLK, 4CLL, 4CLP, 4CLS, 4CLT, 4CLU, 4CLW, 4CLY, 4CLZ, 4CM0, 4CM2, 4OYA, 4OYB, 4OYI, 4OYM, 4OYO, 4OYP, 4OYW, 4OYX, 4OYZ, 4OZ2, 4OZ3, 4UST, 4USU, 4USV, 4USW, 5D0R
Identifiers
Aliases	ADCY10, HCA2, SAC, SACI, Sacy, hsAC, HEL-S-7a, adenylate cyclase 10 (soluble), adenylate cyclase 10, soluble, adenylate cyclase 10
External IDs	OMIM: 605205; MGI: 2660854; HomoloGene: 10188; GeneCards: ADCY10; OMA:ADCY10 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q24.2 Start 167,809,386 bp[1] End 167,914,215 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 H2.3 Start 165,312,752 bp[2] End 165,404,343 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sperm left testis right testis buccal mucosa cell right lobe of liver testicle gonad cerebellar hemisphere right hemisphere of cerebellum mucosa of transverse colon Top expressed in spermatid spermatocyte seminiferous tubule embryo embryo granulocyte morula blastocyst zygote lumbar subsegment of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding manganese ion binding metal ion binding lyase activity adenylate cyclase activity phosphorus-oxygen lyase activity bicarbonate binding ATP binding magnesium ion binding ATPase binding Cellular component cytoplasm cytosol cell projection membrane microtubule cytoskeleton growth cone basal part of cell plasma membrane apical part of cell cilium axon soma dendrite mitochondrion perinuclear region of cytoplasm motile cilium cytoskeleton nucleus apical plasma membrane extracellular region Biological process cellular response to inorganic substance intracellular signal transduction epithelial cilium movement involved in extracellular fluid movement cyclic nucleotide biosynthetic process spermatogenesis positive regulation of apoptotic process cAMP biosynthetic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55811 271639 Ensembl ENSG00000143199 ENSMUSG00000026567 UniProt Q96PN6 Q8C0T9 RefSeq (mRNA) NM_001167749 NM_001297772 NM_018417 NM_173029 NM_001357427 RefSeq (protein) NP_001161221 NP_001284701 NP_060887 NP_766617 NP_001344356 Location (UCSC) Chr 1: 167.81 – 167.91 Mb Chr 1: 165.31 – 165.4 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Function

The protein encoded by this gene belongs to a distinct class of mammalian adenylyl cyclase that is soluble and insensitive to G protein or forskolin regulation. It is localized in the cytoplasm and is thought to function as a general bicarbonate sensor throughout the body. It may also play an important role in the generation of cAMP in spermatozoa, implying possible roles in sperm maturation through the epididymis, capacitation, hypermotility, and/or the acrosome reaction.^[6]

Clinical significance

Mutations in the ADCY10 gene are associated with an increased risk of adsorptive hypercalciuria^[5] and male infertility.^[7]