ADCY3

Adenylyl cyclase type 3 is an enzyme that in humans is encoded by the ADCY3 gene.^[5][6]

ADCY3
Identifiers
Aliases	ADCY3, AC3, AC-III, adenylate cyclase 3, BMIQ19
External IDs	OMIM: 600291; MGI: 99675; HomoloGene: 2978; GeneCards: ADCY3; OMA:ADCY3 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p23.3 Start 24,819,169 bp[1] End 24,920,237 bp[1]
Gene location (Mouse) Chr. Chromosome 12 (mouse)[2] Band 12|12 A1.1 Start 4,183,103 bp[2] End 4,263,525 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial nerve right ovary sural nerve left uterine tube canal of the cervix left ovary stromal cell of endometrium body of uterus ectocervix gastric mucosa Top expressed in gastrula olfactory epithelium brown adipose tissue lumbar subsegment of spinal cord subiculum submandibular gland ventromedial nucleus paraventricular nucleus of hypothalamus suprachiasmatic nucleus superior frontal gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding calmodulin binding lyase activity phosphorus-oxygen lyase activity ATP binding adenylate cyclase activity guanylate cyclase activity Cellular component cytoplasm integral component of membrane Golgi apparatus cell projection membrane plasma membrane integral component of plasma membrane cilium guanylate cyclase complex, soluble Biological process cAMP biosynthetic process activation of protein kinase A activity intracellular signal transduction response to stimulus cellular response to glucagon stimulus cyclic nucleotide biosynthetic process sensory perception of smell renal water homeostasis signal transduction activation of adenylate cyclase activity cGMP biosynthetic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway single fertilization acrosome reaction olfactory learning flagellated sperm motility cellular response to forskolin G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 109 104111 Ensembl ENSG00000138031 ENSMUSG00000020654 UniProt O60266 Q8VHH7 RefSeq (mRNA) NM_004036 NM_001320613 NM_001377128 NM_001377129 NM_001377130 NM_001377131 NM_001377132 NM_001159536 NM_001159537 NM_138305 RefSeq (protein) NP_001307542 NP_004027 NP_001364057 NP_001364058 NP_001364059 NP_001364060 NP_001364061 NP_001153008 NP_001153009 NP_612178 Location (UCSC) Chr 2: 24.82 – 24.92 Mb Chr 12: 4.18 – 4.26 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes adenylyl cyclase 3, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP).^[6]

The ADCY3 subtype likely mediates odorant detection (possibly) via modulation of intracellular cAMP concentration.^[7]