ADCY4

Adenylyl cyclase type 4 is an enzyme that in humans is encoded by the ADCY4 gene.^[5][6]

ADCY4
Identifiers
Aliases	ADCY4, AC4, adenylate cyclase 4
External IDs	OMIM: 600292; MGI: 99674; HomoloGene: 23149; GeneCards: ADCY4; OMA:ADCY4 - orthologs
Gene location (Human) Chr. Chromosome 14 (human)[1] Band 14q12 Start 24,318,349 bp[1] End 24,335,093 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14|14 C3 Start 56,006,514 bp[2] End 56,021,552 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart subcutaneous adipose tissue left uterine tube right lung body of uterus left ventricle lactiferous gland myometrium right lobe of thyroid gland canal of the cervix Top expressed in external carotid artery internal carotid artery right lung lactiferous gland right lung lobe left lung muscle of thigh left lung lobe yolk sac carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding protein binding lyase activity phosphorus-oxygen lyase activity ATP binding guanylate cyclase activity protein kinase C binding adenylate cyclase activity Cellular component cytoplasm integral component of membrane membrane plasma membrane intracellular anatomical structure dendrite guanylate cyclase complex, soluble integral component of plasma membrane Biological process intracellular signal transduction adenylate cyclase-modulating G protein-coupled receptor signaling pathway cellular response to glucagon stimulus cyclic nucleotide biosynthetic process renal water homeostasis cAMP biosynthetic process cGMP biosynthetic process signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 196883 104110 Ensembl ENSG00000129467 ENSG00000284814 ENSMUSG00000022220 UniProt Q8NFM4 Q91WF3 RefSeq (mRNA) NM_139247 NM_001198568 NM_001198592 NM_080435 NM_001361604 RefSeq (protein) NP_001185497 NP_001185521 NP_640340 NP_536683 NP_001348533 Location (UCSC) Chr 14: 24.32 – 24.34 Mb Chr 14: 56.01 – 56.02 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes a member of the family of adenylyl cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Mouse studies show that adenylyl cyclase 4, along with adenylyl cyclases 2 and 3, is expressed in olfactory cilia, suggesting that several different adenylyl cyclases may couple to olfactory receptors and that there may be multiple receptor-mediated mechanisms for the generation of cAMP signals.^[6]