ADCY6

Adenylyl cyclase type 6 is an enzyme that in humans is encoded by the ADCY6 gene.^[5]

ADCY6
Identifiers
Aliases	ADCY6, AC6, LCCS8, adenylate cyclase 6
External IDs	OMIM: 600294; MGI: 87917; HomoloGene: 22400; GeneCards: ADCY6; OMA:ADCY6 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.12 Start 48,766,194 bp[1] End 48,789,089 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15|15 F1 Start 98,487,854 bp[2] End 98,507,957 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in apex of heart left ventricle right auricle of heart mucosa of transverse colon right coronary artery ascending aorta stromal cell of endometrium sural nerve right ovary body of stomach Top expressed in crypt of lieberkuhn of small intestine right ventricle neural layer of retina myocardium of ventricle cardiac muscle tissue of left ventricle submandibular gland atrium medullary collecting duct thymus epithelium of stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding nucleotide binding lyase activity protein kinase binding adenylate cyclase activity phosphorus-oxygen lyase activity ATP binding protein binding guanylate cyclase activity protein kinase C binding Cellular component integral component of membrane cell projection intrinsic component of plasma membrane membrane cilium plasma membrane guanylate cyclase complex, soluble intracellular anatomical structure integral component of plasma membrane stereocilium Biological process negative regulation of neuron projection development intracellular signal transduction cAMP biosynthetic process cellular response to forskolin negative regulation of urine volume cellular response to glucagon stimulus cyclic nucleotide biosynthetic process cellular response to vasopressin cellular response to catecholamine stimulus cellular response to prostaglandin E stimulus dopamine receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway renal water homeostasis cGMP biosynthetic process adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway blood vessel diameter maintenance G protein-coupled receptor signaling pathway activation of adenylate cyclase activity activation of protein kinase A activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 112 11512 Ensembl ENSG00000174233 ENSMUSG00000022994 UniProt O43306 Q01341 RefSeq (mRNA) NM_015270 NM_020983 NM_001390830 NM_001390831 NM_007405 NM_001368413 RefSeq (protein) NP_056085 NP_031431 NP_001355342 Location (UCSC) Chr 12: 48.77 – 48.79 Mb Chr 15: 98.49 – 98.51 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes adenylyl cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants.^[5]