ADCY8

Adenylyl cyclase type 8 is an enzyme that in humans is encoded by the ADCY8 gene.^[4][5]

ADCY8
Identifiers
Aliases	ADCY8, AC8, ADCY3, HBAC1, adenylate cyclase 8 (brain), adenylate cyclase 8
External IDs	OMIM: 103070; MGI: 1341110; HomoloGene: 37443; GeneCards: ADCY8; OMA:ADCY8 - orthologs
Gene location (Mouse) Chr. Chromosome 15 (mouse)[1] Band 15 D1|15 29.03 cM Start 64,568,933 bp[1] End 64,794,145 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in caput epididymis inferior olivary nucleus corpus epididymis external globus pallidus pons amygdala prefrontal cortex cingulate gyrus hypothalamus substantia nigra Top expressed in ventral lateral nucleus central medial nucleus medial dorsal nucleus medial geniculate nucleus supraoptic nucleus lateral geniculate nucleus lumbar subsegment of spinal cord ganglion cell layer layer of neocortex efferent ductule More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding metal ion binding lyase activity adenylate cyclase activity phosphorus-oxygen lyase activity calcium- and calmodulin-responsive adenylate cyclase activity ATP binding guanylate cyclase activity actin binding calmodulin binding protein homodimerization activity protein heterodimerization activity protein dimerization activity protein phosphatase 2A binding Cellular component integral component of membrane membrane plasma membrane guanylate cyclase complex, soluble Schaffer collateral - CA1 synapse hippocampal mossy fiber to CA3 synapse glutamatergic synapse integral component of presynaptic membrane intracellular anatomical structure integral component of plasma membrane caveola clathrin-coated pit postsynaptic density actin cytoskeleton basolateral plasma membrane apical plasma membrane axon dendrite neuronal cell body membrane plasma membrane raft membrane raft presynaptic active zone excitatory synapse cell junction clathrin-coated vesicle membrane cytoplasmic vesicle presynaptic membrane cell projection synapse postsynaptic membrane Biological process cAMP biosynthetic process intracellular signal transduction cellular response to glucagon stimulus cyclic nucleotide biosynthetic process long-term memory renal water homeostasis learning or memory signal transduction cGMP biosynthetic process adenylate cyclase-activating G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway modulation of chemical synaptic transmission positive regulation of cytosolic calcium ion concentration memory locomotory behavior glucose mediated signaling pathway positive regulation of synaptic plasticity positive regulation of CREB transcription factor activity activation of protein kinase A activity positive regulation of insulin secretion involved in cellular response to glucose stimulus G protein-coupled opioid receptor signaling pathway glucose homeostasis protein complex oligomerization protein homooligomerization regulation of cytosolic calcium ion concentration cellular response to calcium ion cellular response to morphine cellular response to glucose stimulus regulation of cellular response to stress neuroinflammatory response positive regulation of long-term synaptic potentiation positive regulation of long-term synaptic depression cellular response to forskolin activation of adenylate cyclase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 114 11514 Ensembl n/a ENSMUSG00000022376 UniProt P40145 Q4F7X0 P97490 RefSeq (mRNA) NM_001115 NM_001291903 NM_009623 NM_001331075 RefSeq (protein) NP_001106 NP_001106.1 NP_001278832 NP_001318004 NP_033753 Location (UCSC) n/a Chr 15: 64.57 – 64.79 Mb PubMed search [2] [3]
Wikidata
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Function

Adenylyl cyclase is a membrane bound enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (R_s and R_i) interact with G proteins (G_s and G_i) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase.^[5]