ADD2

For the ADD2 graphics expansion card system, see SDVO.

Beta-adducin is a protein that in humans is encoded by the ADD2 gene.^[5][6]

ADD2
Identifiers
Aliases	ADD2, ADDB, adducin 2
External IDs	OMIM: 102681; MGI: 87919; HomoloGene: 1221; GeneCards: ADD2; OMA:ADD2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2p13.3 Start 70,607,618 bp[1] End 70,768,225 bp[1]
Gene location (Mouse) Chr. Chromosome 6 (mouse)[2] Band 6 C3- D1|6 37.55 cM Start 86,005,663 bp[2] End 86,101,391 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 middle temporal gyrus Brodmann area 23 paraflocculus of cerebellum frontal pole Region I of hippocampus proper postcentral gyrus Brodmann area 46 entorhinal cortex superior frontal gyrus Top expressed in olfactory tubercle Region I of hippocampus proper piriform cortex dentate gyrus facial motor nucleus central gray substance of midbrain dentate gyrus of hippocampal formation granule cell subiculum pontine nuclei visual cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function spectrin binding protein homodimerization activity structural molecule activity calmodulin binding actin filament binding protein heterodimerization activity actin binding protein kinase binding Cellular component F-actin capping protein complex cytoplasm cytosol membrane plasma membrane cytoskeleton postsynaptic density cytoplasmic vesicle plasma membrane raft Biological process barbed-end actin filament capping actin filament bundle assembly transmembrane transport positive regulation of protein binding actin cytoskeleton organization leukocyte migration leukocyte tethering or rolling protein-containing complex assembly hemopoiesis synapse assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 119 11519 Ensembl ENSG00000075340 ENSMUSG00000030000 UniProt P35612 Q9QYB8 RefSeq (mRNA) NM_001185054 NM_001185055 NM_001617 NM_017482 NM_017483 NM_017484 NM_017485 NM_017486 NM_017487 NM_017488 NM_001271857 NM_001271858 NM_001271859 NM_001271860 NM_001271861 NM_013458 RefSeq (protein) NP_001171983 NP_001171984 NP_001608 NP_059516 NP_059522 NP_001258786 NP_001258787 NP_001258788 NP_001258789 NP_001258790 NP_038486 Location (UCSC) Chr 2: 70.61 – 70.77 Mb Chr 6: 86.01 – 86.1 Mb PubMed search [3] [4]
Wikidata
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Function

Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta, and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues.

While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is composed of two distinct domains.

The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Various adducin beta mRNAs, alternatively spliced at 3' end and/or internally spliced and encoding different isoforms, have been described. The functions of all the different isoforms are not known.^[6]

Interactions

ADD2 has been shown to interact with FYN.^[7]