ADH7

Alcohol dehydrogenase class 4 mu/sigma chain is an enzyme that in humans is encoded by the ADH7 gene.^[5][6]

ADH7
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AGN, 1D1S, 1D1T
Identifiers
Aliases	ADH7, ADH4, alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
External IDs	OMIM: 600086; MGI: 87926; HomoloGene: 37333; GeneCards: ADH7; OMA:ADH7 - orthologs
Gene location (Human) Chr. Chromosome 4 (human)[1] Band 4q23 Start 99,412,261 bp[1] End 99,435,510 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3 G3|3 64.13 cM Start 137,923,521 bp[2] End 137,939,143 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in olfactory zone of nasal mucosa oral cavity nasal epithelium epithelium of nasopharynx mucosa of pharynx mucosa of paranasal sinus gums gingival epithelium testicle palpebral conjunctiva Top expressed in esophagus superior surface of tongue gastric mucosa mucous cell of stomach epithelium of stomach pyloric antrum transitional epithelium of urinary bladder lip corneal stroma conjunctival fornix More reference expression data BioGPS More reference expression data
Gene ontology Molecular function aldehyde oxidase activity zinc ion binding metal ion binding NAD-retinol dehydrogenase activity ethanol binding retinol binding oxidoreductase activity receptor antagonist activity alcohol dehydrogenase (NAD+) activity alcohol dehydrogenase activity, zinc-dependent Cellular component cytoplasm intracellular anatomical structure extracellular region cytosol plasma membrane Biological process ethanol catabolic process response to bacterium retinol metabolic process retinoic acid metabolic process fatty acid omega-oxidation retinoid metabolic process response to ethanol ethanol oxidation extracellular negative regulation of signal transduction negative regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 131 11529 Ensembl ENSG00000196344 ENSMUSG00000055301 UniProt P40394 Q64437 RefSeq (mRNA) NM_001166504 NM_000673 NM_009626 RefSeq (protein) NP_000664 NP_001159976 NP_033756 Location (UCSC) Chr 4: 99.41 – 99.44 Mb Chr 3: 137.92 – 137.94 Mb PubMed search [3] [4]
Wikidata
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Function

This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members.^[6]