ADI1

The human ADI1 gene encodes the enzyme 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.^[4][5][6]

ADI1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4QGN
Identifiers
Aliases	ADI1, APL1, ARD, Fe-ARD, MTCBP1, Ni-ARD, SIPL, mtnD, HMFT1638, acireductone dioxygenase 1
External IDs	OMIM: 613400; MGI: 2144929; HomoloGene: 75081; GeneCards: ADI1; OMA:ADI1 - orthologs
Gene location (Mouse) Chr. Chromosome 12 (mouse)[1] Band 12|12 A2 Start 28,725,230 bp[1] End 28,732,174 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver kidney ascending aorta duodenum left ventricle right coronary artery left coronary artery gallbladder fundus left adrenal gland Top expressed in left lobe of liver muscle of thigh Paneth cell right kidney triceps brachii muscle embryo crypt of lieberkuhn of small intestine medial head of gastrocnemius muscle tail of embryo vastus lateralis muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding dioxygenase activity metal ion binding oxidoreductase activity acireductone dioxygenase [iron(II)-requiring activity] iron ion binding Cellular component cytosol membrane plasma membrane nucleus cytoplasm Biological process methionine biosynthetic process cellular amino acid biosynthetic process L-methionine salvage from methylthioadenosine methionine metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55256 104923 Ensembl n/a ENSMUSG00000020629 UniProt Q9BV57 Q99JT9 RefSeq (mRNA) NM_001306077 NM_018269 NM_134052 RefSeq (protein) NP_001293006 NP_060739 NP_598813 Location (UCSC) n/a Chr 12: 28.73 – 28.73 Mb PubMed search [2] [3]
Wikidata
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Function

The enzyme belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization.

Clinical significance

Diseases associated with ADI1 include Klebsiella, and refsum disease.

ADI1 is capable for supporting hepatitis C virus replication in an otherwise non-permissive cell line.^[7] Mouse hepatoma cells coexpressing human CD81 and ADI1/Sip-L supported HCV infection and replication.^[8] Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.^[9][10]